Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Kinase structure
Kinase:PIK3CA (p110a)
Family:PIK
Group:Atypical
Species:HUMAN
IUPHAR/BPS ID:2153
PDB:8OW2
sc-PDB:
KIDFamMap:Search
Release date:2023-05-24
PubMed: 37225977
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 8OW2
8OW2Alternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):56.3° (16.8Å)
G-rich loop rotation:89.5°
Quality Score:8
Resolution:2.57 Å
Missing Residues:0
Missing Atoms:0

Allosteric Ligand
Allosteric ligand:QIH
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:CRIMSSAKRPLWLIIFKNGDLRQDMLTLQIIRLRMLPYGCLVGLIEVVRSHTIMQIQCKATFI--LGIGDRHNSNIMVHIDFGHF
Sequence structure:CRIMSSAKRPLWLIIFKNGDLRQDMLTLQIIRLRMLPYGCLVGLIEVVRSHTIMQIQCKATFI__LGIGDRHNSNIMVHIDFGHF