3-phosphoinositide dependent protein kinase 1
Kinase structure
Kinase:PDPK1 (PDK1)
Family:PDK1
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1519
PDB:8DQT
sc-PDB:
KIDFamMap:Search
Release date:2023-06-21
PubMed: 37311034
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):61° (17.7Å)
G-rich loop rotation:43.6°
Quality Score:8
Resolution:1.31 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I3
I4
I8
Ligand
No
No
No
No
Protein
Yes
No
Yes
Yes

Allosteric Ligand
Allosteric ligand:U35
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:KILGEGSFSTVVLYAIKILYVTRERDVMSRLDPFFVKLYFTYFGLSYAKNGELLKYIRKYLHGKGIIHRDLKPENILLITDFGTA
Sequence structure:KILGEGSFSTVVLYAIKILYVTRERDVMSRLDPFFVKLYFTYFGLSYAKNGELLKYIRKYLHGKGIIHRDLKPENILLITDFGTA