Insulin receptor
Kinase structure
Kinase:INSR
Family:InsR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1800
PDB:8DWN
sc-PDB:
KIDFamMap:Search
Release date:2023-08-16
Chain:A
Click to open a 3D viewer
The orthosteric binding pocket
Structural information
DFG conformation:na
αC-helix conformation:in
G-rich loop angle (distance):62.4° (18.3Å)
G-rich loop rotation:78.3°
Quality Score:6
Resolution:2.15 Å
Missing Residues:4
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I2
I3
I5
Ligand
No
No
No
Protein
Yes
Yes
No

Pocket alignment
Uniprot sequence:RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT-HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT
Sequence structure:RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT_HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGD____