Search results (46 entries covering 29 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	INSR	InsR	TK	1irk	A	A	-	Human	Show
	INSR	InsR	TK	4ibm	B	B	5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one	Human	Show
	INSR	InsR	TK	5e1s	A	B	(5r)-n-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1h-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5h-pyrazolo[3,4-h]quinazolin-2-amine	Human	Show
	INSR	InsR	TK	8u4b	A		-	Human	Show
	INSR	InsR	TK	8dwn	A		-	Human	Show
	INSR	InsR	TK	4xlv	A		phosphomethylphosphonic acid adenylate ester	Human	Show
	INSR	InsR	TK	1rqq	A		thiophosphoric acid o-((adenosyl-phospho)phospho)-s-acetamidyl-diester	Human	Show
	INSR	InsR	TK	1p14	A		-	Human	Show
	INSR	InsR	TK	1gag	A		-	Human	Show
	INSR	InsR	TK	4ibm	B	A	5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one	Human	Show
	INSR	InsR	TK	7bw8	A		-	Human	Show
	INSR	InsR	TK	3bu6	A		-	Human	Show
	INSR	InsR	TK	4ibm	A	A	5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one	Human	Show
	INSR	InsR	TK	7pg2	A		-	Human	Show
	INSR	InsR	TK	7bw7	A		-	Human	Show
	INSR	InsR	TK	6pxv	C		-	Human	Show
	INSR	InsR	TK	6pxv	A		-	Human	Show
	INSR	InsR	TK	3ekk	A	B	2-[(2-{[1-(n,n-dimethylglycyl)-5-methoxy-1h-indol-6-yl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-n-methylbenzamide	Human	Show
	INSR	InsR	TK	2b4s	D		-	Human	Show
	INSR	InsR	TK	3eta	A	B	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	Show
	INSR	InsR	TK	3eta	B	A	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	Show
	INSR	InsR	TK	2b4s	B		-	Human	Show
	INSR	InsR	TK	7pg3	A		-	Human	Show
	INSR	InsR	TK	3ekn	A	A	2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide	Human	Show
	INSR	InsR	TK	1rqq	B		thiophosphoric acid o-((adenosyl-phospho)phospho)-s-acetamidyl-diester	Human	Show
	INSR	InsR	TK	2z8c	A		[4-({5-(aminocarbonyl)-4-[(3-methylphenyl)amino]pyrimidin-2-yl}amino)phenyl]acetic acid	Human	Show
	INSR	InsR	TK	1i44	A		phosphomethylphosphonic acid adenylate ester	Human	Show
	INSR	InsR	TK	7bw7	C		-	Human	Show
	INSR	InsR	TK	1ir3	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	INSR	InsR	TK	7pg0	A		-	Human	Show
	INSR	InsR	TK	5e1s	A	A	(5r)-n-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1h-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5h-pyrazolo[3,4-h]quinazolin-2-amine	Human	Show
	INSR	InsR	TK	3ekn	A	B	2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide	Human	Show
	INSR	InsR	TK	7bw8	C		-	Human	Show
	INSR	InsR	TK	2auh	A		-	Human	Show
	INSR	InsR	TK	3bu3	A		-	Human	Show
	INSR	InsR	TK	3eta	B	B	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	Show
	INSR	InsR	TK	3eta	A	A	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	Show
	INSR	InsR	TK	3bu5	A		adenosine-5'-triphosphate	Human	Show
	INSR	InsR	TK	6pxw	B		-	Human	Show
	INSR	InsR	TK	5hhw	A	A	7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	INSR	InsR	TK	6pxw	A		-	Human	Show
	INSR	InsR	TK	3ekk	A	A	2-[(2-{[1-(n,n-dimethylglycyl)-5-methoxy-1h-indol-6-yl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-n-methylbenzamide	Human	Show
	INSR	InsR	TK	1irk	A	B	-	Human	Show
	INSR	InsR	TK	5hhw	A	B	7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	INSR	InsR	TK	4ibm	A	B	5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one	Human	Show
	INSR	InsR	TK	7pg4	A		-	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam