Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Kinase structure
Kinase:PIK3CA (p110a)
Family:PIK
Group:Atypical
Species:HUMAN
IUPHAR/BPS ID:2153
PDB:8TSA
sc-PDB:
KIDFamMap:Search
Release date:2023-11-22
PubMed: 37916956
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):63.3° (18.9Å)
G-rich loop rotation:92.7°
Quality Score:7.6
Resolution:2.51 Å
Missing Residues:0
Missing Atoms:0

Allosteric Ligand
Allosteric ligand:UIW
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:CRIMSSAKRPLWLIIFKNGDLRQDMLTLQIIRLRMLPYGCLVGLIEVVRSHTIMQIQCKATFI--LGIGDRHNSNIMVHIDFGHF
Sequence structure:CRIMSSAKRPLWLIIFKNGDLRQDMLTLQIIRLRMLPYGCLVGLIEVVRSHTIMQIQCKATFI__LGIGDRHNSNIMVHIDFGHF