PDB-code
| Kinase structure | |
| Kinase: | SIK3 (QSK) |
| Family: | CAMKL |
| Group: | CAMK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2199 |
| PDB: | 8R4Q |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2024-03-27 |
| PubMed: | 38508313 |
| Chain: | A |
| Orthosteric ligand: | DB8 |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 55.1° (16.3Å) |
| G-rich loop rotation: | 80° |
| Quality Score: | 9.6 |
| Resolution: | 2.838 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 4 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front gate | FP-I BP-I-A BP-I-B | |||
| Pocket alignment | |
| Uniprot sequence: | RTIGKGNFAVVKRVAIKIIKIFREVQIMKMLCPHIIRLYQVYLVTEYASGGEIFDHLVAFCHCRNIVHRDLKAENLLLIADFGFS |
| Sequence structure: | RTIGKGNFAVVKRVAIKIIKIFREVQIMKMLSPHIIRLYQVYLVTEYASGGEIFDHLVAFCHSRNIVHRDLKAENLLLIADFGFS |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL288441 |
| Bioaffinities: | 348 records for 195 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | Adaptor-associated kinase | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 7 | 7 | 7 | pIC50 | 1 |
| Homo sapiens | CaM kinase I delta | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | CaM kinase II gamma | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
| Homo sapiens | CaM kinase II gamma | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Casein kinase I alpha | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Casein kinase I delta | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Casein kinase I epsilon | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Casein kinase I isoform alpha-like | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Citron Rho-interacting kinase | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 9 | 9 | 9 | pIC50 | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 7 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 5.8 | 5.8 | 5.8 | pKd | 2 |
| Homo sapiens | Dual specificity protein kinase CLK3 | 6.5 | 6.5 | 6.5 | pKd | 2 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 6.2 | 6.2 | 6.2 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 5 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 8 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 8.1 | 8.1 | 8.1 | pIC50 | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 3 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 8.3 | 8.3 | 8.3 | pIC50 | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 7.4 | 6.4 | 7.8 | pKd | 12 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 2 |
| Homo sapiens | G protein-coupled receptor kinase 4 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 7 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 5.5 | 5.2 | 5.7 | pKd | 3 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Hormonally up-regulated neu tumor-associated kinase | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 6.1 | 6.1 | 6.3 | pKd | 2 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Microtubule-associated serine/threonine-protein kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 7.7 | 7.7 | 7.7 | pIC50 | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 7 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 9.5 | 9.5 | 9.5 | pIC50 | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 9.3 | 9.3 | 9.3 | pKd | 1 |
| Homo sapiens | Mixed lineage kinase 7 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Myosin IIIA | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Myotonin-protein kinase | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 7.7 | 7.7 | 7.7 | pIC50 | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 7.6 | 7.6 | 7.6 | pIC50 | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | NT-3 growth factor receptor | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Protein kinase C delta | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Protein kinase C epsilon | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Protein kinase C theta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Protein kinase N1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 6.9 | 6.9 | 6.9 | pIC50 | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 5.6 | 5.6 | 5.6 | pIC50 | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Receptor tyrosine-protein kinase erbB-3 | 9.1 | 9.1 | 9.1 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 5.5 | 5.5 | 5.5 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 5.9 | 5.9 | 5.9 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 6 | 5.6 | 5.6 | 5.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 8.4 | 8.4 | 8.4 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32A | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 36 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase GAK | 8.9 | 8.9 | 8.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek11 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NIM1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine protein kinase NLK | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIPK2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase WEE1 | 6.3 | 6.3 | 7.1 | pKd | 2 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | STE20/SPS1-related proline-alanine-rich protein kinase | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 6.7 | 5.2 | 7.5 | pIC50 | 5 |
| Homo sapiens | Stem cell growth factor receptor | 6.6 | 6.3 | 7.1 | pKd | 7 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.2 | 6.2 | 6.9 | pIC50 | 2 |
| Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.5 | 6.5 | 6.6 | pKd | 2 |
| Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.5 | 6.5 | 7.9 | pKi | 2 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 8.6 | 8.6 | 8.6 | pIC50 | 2 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 9 | 6.3 | 9.3 | pIC50 | 6 |
| Homo sapiens | Tyrosine-protein kinase ABL | 10.1 | 7.7 | 10.5 | pKd | 16 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 9.3 | 9.3 | 9.3 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 8.8 | 8.8 | 8.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Mus musculus | Tyrosine-protein kinase BLK | 8.1 | 8.1 | 8.1 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 8.1 | 8.1 | 9 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase BMX | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 8.6 | 8.6 | 8.6 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase CSK | 7.2 | 7.2 | 7.2 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase CSK | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase CTK | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 6.5 | 6.5 | 6.5 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 9 | 9 | 9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 8.7 | 8.7 | 8.7 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 8.9 | 8.9 | 8.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 6.4 | 6.4 | 8.7 | pIC50 | 3 |
| Homo sapiens | Tyrosine-protein kinase FYN | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 8.5 | 8.5 | 8.5 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 8.5 | 8.5 | 8.5 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 6 | 6 | 6 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 5.9 | 5.9 | 5.9 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 8.9 | 8.9 | 8.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase LCK | 9.2 | 9.2 | 9.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 8.1 | 8.1 | 8.1 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 5.7 | 5.5 | 6 | pKd | 7 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 5.4 | 5.3 | 5.4 | pKd | 3 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 6.5 | 6.3 | 6.8 | pIC50 | 3 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 8.4 | 7 | 9 | pIC50 | 32 |
| Homo sapiens | Tyrosine-protein kinase SRC | 9 | 9 | 9 | pKd | 3 |
| Homo sapiens | Tyrosine-protein kinase Srms | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 6.6 | 6.6 | 6.6 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 5.2 | 5.2 | 5.4 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase YES | 9.4 | 9.4 | 9.4 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase YES | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Wee1-like protein kinase 2 | 7 | 7 | 7 | pKd | 2 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 70 | 2 T 71 | 3 I 72 | 4 G 73 | 5 K 74 | 6 G 75 | 7 N 76 | 8 F 77 | 9 A 78 | 10 V 79 | 11 V 80 | 12 K 81 | 13 R 82 | 14 V 92 | 15 A 93 | 16 I 94 | 17 K 95 | 18 I 96 | 19 I 97 | 20 K 109 |
| • | • | • | • | • | • | ||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 110 | 22 F 111 | 23 R 112 | 24 E 113 | 25 V 114 | 26 Q 115 | 27 I 116 | 28 M 117 | 29 K 118 | 30 M 119 | 31 L 120 | 32 S 121 | 33 P 123 | 34 H 124 | 35 I 125 | 36 I 126 | 37 R 127 | 38 L 128 | 39 Y 129 | 40 Q 130 |
| • | • | ||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 131 | 42 Y 139 | 43 L 140 | 44 V 141 | 45 T 142 | 46 E 143 | 47 Y 144 | 48 A 145 | 49 S 146 | 50 G 147 | 51 G 148 | 52 E 149 | 53 I 150 | 54 F 151 | 55 D 152 | 56 H 153 | 57 L 154 | 58 V 155 | 59 A 156 | 60 F 178 |
| • | •• | • | •• | • | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 C 179 | 62 H 180 | 63 S 181 | 64 R 182 | 65 N 183 | 66 I 184 | 67 V 185 | 68 H 186 | 69 R 187 | 70 D 188 | 71 L 189 | 72 K 190 | 73 A 191 | 74 E 192 | 75 N 193 | 76 L 194 | 77 L 195 | 78 L 196 | 79 I 204 | 80 A 205 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 206 | 82 F 207 | 83 G 208 | 84 F 209 | 85 S 210 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
