Version: 3.2
Updated: 29-Oct-2025
Mitogen-activated protein kinase-activated protein kinase 2
Kinase structure
Kinase:MAPKAPK2
Family:MAPKAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2094
PDB:8XX1
sc-PDB:
KIDFamMap:Search
Release date:2024-03-06
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 8XX1
8XX1Alternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):70.5° (20.1Å)
G-rich loop rotation:88.4°
Quality Score:8
Resolution:2.55 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I2
I4
I5
Ligand
No
No
No
No
Protein
No
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA
Sequence structure:QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA