Version: 3.2
Updated: 24-Dec-2025
P21 protein (Cdc42/Rac)-activated kinase 1
Kinase structure
Kinase:PAK1
Family:STE20
Group:STE
Species:HUMAN
IUPHAR/BPS ID:2133
PDB:1YHW
sc-PDB:
KIDFamMap:Search
Release date:2005-05-24
PubMed: 15893667
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):66.2° (19.9Å)
G-rich loop rotation:38.2°
Quality Score:9.5
Resolution:1.8 Å
Missing Residues:0
Missing Atoms:5
Ligand binding mode
Waters
Cluster
I1
I2
I4
I6
I8
I9
I10
Ligand
No
No
No
No
No
No
No
Protein
Yes
Yes
Yes
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:EKIGQGASGTVYTVAIKQMLIINEILVMRENKPNIVNYLDSWVVMEYLAGGSLTDVVTEFLHSNQVIHRDIKSDNILLLTDFGFC
Sequence structure:EKIGQGASGTVYTVAIRQMLIINEILVMRENKPNIVNYLDSWVVMEYLAGGSLTDVVTEFLHSNQVIHRDIKSDNILLLTDFGFC