Search results (70 entries covering 29 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	PAK1	STE20	STE	4zji	D	B	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	5dew	A		8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	4zlo	A	A	2,8-difluoro-11-(4-methylpiperazin-1-yl)-5h-dibenzo[b,e][1,4]diazepine	Human	Show
	PAK1	STE20	STE	4zjj	A	B	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	1yhw	A		-	Human	Show
	PAK1	STE20	STE	3fxz	A	A	octahedral ru-pyridocarbazole	Human	Show
	PAK1	STE20	STE	4daw	A	B	[1,3-dioxo-6-(pyridin-2-yl-kappan)-2,3-dihydro-1h-isoindol-5-yl-kappac~5~][(thioxomethylidene)azanido-kappan](1,4,7-trithionane-kappa~3~s~1~,s~4~,s~7~)ruthenium	Human	Show
	PAK1	STE20	STE	4zji	C	B	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	4o0r	A		pf-3758309	Human	Show
	PAK1	STE20	STE	3fxz	A	B	octahedral ru-pyridocarbazole	Human	Show
	PAK1	STE20	STE	4zji	D	A	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	4zji	B	B	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	4zlo	A	B	2,8-difluoro-11-(4-methylpiperazin-1-yl)-5h-dibenzo[b,e][1,4]diazepine	Human	Show
	PAK1	STE20	STE	4zji	C	A	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	5dey	A		8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	4zji	A	B	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	3q4z	B	A	-	Human	Show
	PAK1	STE20	STE	5ime	A		8-(3-aminopropyl)-6-[2-chloro-4-(3-methyl-2-oxopyrazin-1(2h)-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	4zji	A	A	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	4zjj	B	A	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	1f3m	D		-	Human	Show
	PAK1	STE20	STE	5dfp	A	A	6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	5kbr	A		(4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridin-3-yl]methanone	Human	Show
	PAK1	STE20	STE	4zjj	B	B	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	4zlo	B	B	-	Human	Show
	PAK1	STE20	STE	4eqc	A	B	6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	4zy4	B		2-(4-aminopiperidin-1-yl)-n-(5-cyclopropyl-1h-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amine	Human	Show
	PAK1	STE20	STE	4zy6	B	A	n~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	3q53	A		adenosine-5'-triphosphate	Human	Show
	PAK1	STE20	STE	4zjj	D	A	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	4zy6	A	B	n~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	5kbq	B		-	Human	Show
	PAK1	STE20	STE	4zy4	A		2-(4-aminopiperidin-1-yl)-n-(5-cyclopropyl-1h-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amine	Human	Show
	PAK1	STE20	STE	8x5z	A	B	-	Human	Show
	PAK1	STE20	STE	4daw	A	A	[1,3-dioxo-6-(pyridin-2-yl-kappan)-2,3-dihydro-1h-isoindol-5-yl-kappac~5~][(thioxomethylidene)azanido-kappan](1,4,7-trithionane-kappa~3~s~1~,s~4~,s~7~)ruthenium	Human	Show
	PAK1	STE20	STE	4o0t	A		1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1h-benzimidazol-6-yl}ethynyl)cyclohexanol	Human	Show
	PAK1	STE20	STE	5dfp	A	B	6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	1f3m	C		-	Human	Show
	PAK1	STE20	STE	5dey	B		8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	5kbr	B		(4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridin-3-yl]methanone	Human	Show
	PAK1	STE20	STE	6b16	B		n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)-n~2~-[(1s)-1-(1h-pyrrolo[3,2-b]pyridin-5-yl)ethyl]pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	4o0t	B		-	Human	Show
	PAK1	STE20	STE	5ime	B		8-(3-aminopropyl)-6-[2-chloro-4-(3-methyl-2-oxopyrazin-1(2h)-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	8x5z	A	A	-	Human	Show
	PAK1	STE20	STE	3fy0	A		ruthenium pyridocarbazole	Human	Show
	PAK1	STE20	STE	4zy6	B	B	n~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	4p90	A		[2-chloro-5-(hydroxymethyl)phenyl]{5-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl}methanone	Human	Show
	PAK1	STE20	STE	2hy8	1		(5s,6r,7r,9r)-12-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9-tetrahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one	Human	Show
	PAK1	STE20	STE	4zlo	B	A	-	Human	Show
	PAK1	STE20	STE	4zjj	C	A	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	4zy5	A		n~2~-[(trans-4-aminocyclohexyl)methyl]-n~4~-(3-cyclopropyl-1h-pyrazol-5-yl)pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	4p90	B		[2-chloro-5-(hydroxymethyl)phenyl]{5-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl}methanone	Human	Show
	PAK1	STE20	STE	5dew	B		8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	4zy6	A	A	n~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	3q4z	B	B	-	Human	Show
	PAK1	STE20	STE	4zjj	A	A	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	1yhv	A		-	Human	Show
	PAK1	STE20	STE	4zy5	B		n~2~-[(trans-4-aminocyclohexyl)methyl]-n~4~-(3-cyclopropyl-1h-pyrazol-5-yl)pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	7vto	A	A	4-[(7-oxo-7h-thiazolo[5,4-e]indol-8-ylmethyl)-amino]-n-pyridin-2-yl-benzenesulfonamide	Human	Show
	PAK1	STE20	STE	3q52	A		-	Human	Show
	PAK1	STE20	STE	4zji	B	A	2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin-1-yl)-dibenzodiazepine	Human	Show
	PAK1	STE20	STE	5kbq	A		[4-methyl-3-[methyl-[2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]pyrimidin-4-yl]amino]phenyl]methanol	Human	Show
	PAK1	STE20	STE	4eqc	A	A	6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8h)-one	Human	Show
	PAK1	STE20	STE	4o0r	B		-	Human	Show
	PAK1	STE20	STE	7vto	A	B	4-[(7-oxo-7h-thiazolo[5,4-e]indol-8-ylmethyl)-amino]-n-pyridin-2-yl-benzenesulfonamide	Human	Show
	PAK1	STE20	STE	3q4z	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	PAK1	STE20	STE	6b16	A		n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)-n~2~-[(1s)-1-(1h-pyrrolo[3,2-b]pyridin-5-yl)ethyl]pyrimidine-2,4-diamine	Human	Show
	PAK1	STE20	STE	3q4z	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	PAK1	STE20	STE	4zjj	D	B	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show
	PAK1	STE20	STE	4zjj	C	B	(s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro-dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam