Version: 3.2
Updated: 01-Nov-2025
Interleukin 1 receptor associated kinase 4
Kinase structure
Kinase:IRAK4
Family:IRAK
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:2045
PDB:2O8Y
sc-PDB:
KIDFamMap:Search
Release date:2007-12-25
Chain:A
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The orthosteric binding pocket


More entries for 2O8Y
2O8YChain: B


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):54.1° (16.8Å)
G-rich loop rotation:51.8°
Quality Score:8
Resolution:2.4 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I3
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:NKMGEGGFGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA
Sequence structure:NKMGEGGFGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA