PDB-code
| Kinase structure | |
| Kinase: | FGFR3 |
| Family: | FGFR |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1810 |
| PDB: | 4K33 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2013-09-11 |
| PubMed: | 23972473 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | ACP |
 | |
| More entries for 4K33 | |||||
| 4K33 | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 52.8° (15.8Å) |
| G-rich loop rotation: | 42.1° |
| Quality Score: | 8 |
| Resolution: | 2.34 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-II | Cluster I1 I3 I4 I5 I7 I11 | Ligand Yes Yes No No Yes Yes | Protein Yes Yes Yes Yes Yes No |
| Pocket alignment | |
| Uniprot sequence: | KPLGEGCFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVLVEYAAKGNLREFLRAYLASQKCIHRDLAARNVLVIADFGLA |
| Sequence structure: | KPLGEGAFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVLVEYAAKGNLREFLRAYLASQKCIHRDLAARNVLVIADFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL133463 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 476 | 2 P 477 | 3 L 478 | 4 G 479 | 5 E 480 | 6 G 481 | 7 A 482 | 8 F 483 | 9 G 484 | 10 Q 485 | 11 V 486 | 12 V 487 | 13 M 488 | 14 V 505 | 15 A 506 | 16 V 507 | 17 K 508 | 18 M 509 | 19 L 510 | 20 D 521 |
| • | • | • | • | • | •• | • | • | • | |||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 522 | 22 V 523 | 23 S 524 | 24 E 525 | 25 M 526 | 26 E 527 | 27 M 528 | 28 M 529 | 29 K 530 | 30 M 531 | 31 I 532 | 32 G 533 | 33 K 536 | 34 N 537 | 35 I 538 | 36 I 539 | 37 N 540 | 38 L 541 | 39 L 542 | 40 G 543 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 A 544 | 42 Y 552 | 43 V 553 | 44 L 554 | 45 V 555 | 46 E 556 | 47 Y 557 | 48 A 558 | 49 A 559 | 50 K 560 | 51 G 561 | 52 N 562 | 53 L 563 | 54 R 564 | 55 E 565 | 56 F 566 | 57 L 567 | 58 R 568 | 59 A 569 | 60 Y 607 |
| • | • | •• | •• | •• | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 608 | 62 A 609 | 63 S 610 | 64 Q 611 | 65 K 612 | 66 C 613 | 67 I 614 | 68 H 615 | 69 R 616 | 70 D 617 | 71 L 618 | 72 A 619 | 73 A 620 | 74 R 621 | 75 N 622 | 76 V 623 | 77 L 624 | 78 V 625 | 79 I 633 | 80 A 634 |
| • | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 635 | 82 F 636 | 83 G 637 | 84 L 638 | 85 A 639 | |||||||||||||||
| •• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
