V-akt murine thymoma viral oncogene homolog 2
Kinase structure
Kinase:AKT2
Family:Akt
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1480
PDB:1GZN
sc-PDB:
KIDFamMap:Search
Release date:2003-05-22
PubMed: 12086620
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out-like
αC-helix conformation:in
G-rich loop angle (distance):61.2° (18.4Å)
G-rich loop rotation:49.5°
Quality Score:5.6
Resolution:2.5 Å
Missing Residues:3
Missing Atoms:30
Ligand binding mode
Waters
Cluster
I1
I3
I6
I7
I10
Ligand
No
No
No
No
No
Protein
Yes
Yes
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:KLLGKGTFGKVILYAMKILHTVTESRVLQNTRPFLTALKYACFVMEYANGGELFFHLSRYLHSRDVVYRDIKLENLMLITDFGLC
Sequence structure:KLLGKGTFGKVILYAMKIL__VTESRVLQNTRPFLTALKYACFVMEYANGGELFFHLSRYLHSRDVVYRDIKLENLMLITDFGL_