KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	AURKA (AurA)
Family:	Aur
Group:	Other
Species:	HUMAN
IUPHAR/BPS ID:	1936
PDB:	2WTV
sc-PDB:
KIDFamMap:	Search
Release date:	2010-01-26
PubMed:	20067443
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	ZZL

More entries for 2WTV
2WTV	Alternative model:	A	Chain:	B
2WTV	Alternative model:	A	Chain:	C
2WTV	Alternative model:	A	Chain:	D
2WTV	Alternative model:	B	Chain:	A
2WTV	Alternative model:	B	Chain:	B
2WTV	Alternative model:	B	Chain:	C
2WTV	Alternative model:	B	Chain:	D

Structural information
DFG conformation:	out-like
αC-helix conformation:	in
G-rich loop angle (distance):	71.9° (20.2Å)
G-rich loop rotation:	71.8°
Quality Score:	7.6
Resolution:	2.4 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front		Cluster I5	Ligand Yes	Protein Yes

Pocket alignment
Uniprot sequence:	RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKRVIHRDIKPENLLLIADFGWS
Sequence structure:	RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPRGEVYKELQKYCHSKRVIHRDIKPENLLLIADFGWS

Ligand affinity
ChEMBL ID:	CHEMBL259084
Bioaffinities:	189 records for 71 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	6.1	6.1	6.1	pKi	1
Homo sapiens	Casein kinase II alpha	4.7	4.7	4.7	pIC50	1
Homo sapiens	Casein kinase II alpha	5.4	5.4	5.4	pKi	1
Homo sapiens	Death-associated protein kinase 2	5	5	5	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	5.5	5.5	5.5	pKd	2
Homo sapiens	Dual specificity protein kinase CLK3	5.6	5.6	5.6	pKd	2
Homo sapiens	Dual specificity protein kinase CLK4	5.6	5.6	5.6	pKi	1
Homo sapiens	Ephrin type-A receptor 1	5.8	5.8	5.8	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.4	6.4	6.4	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.9	6.9	6.9	pKi	1
Homo sapiens	Ephrin type-A receptor 3	5.7	5.7	5.7	pKd	2
Homo sapiens	Ephrin type-A receptor 4	6.4	6.4	6.4	pKd	2
Homo sapiens	Ephrin type-A receptor 5	5.9	5.9	5.9	pKd	2
Homo sapiens	Ephrin type-A receptor 6	6.2	6.2	6.2	pKd	2
Homo sapiens	Ephrin type-A receptor 7	6	6	6	pKd	2
Homo sapiens	Ephrin type-B receptor 1	6.5	6.5	6.5	pKd	2
Homo sapiens	Ephrin type-B receptor 3	5.5	5.5	5.5	pKd	2
Homo sapiens	Ephrin type-B receptor 4	6.3	6.3	6.3	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	5.2	5.2	5.5	pKd	4
Homo sapiens	Epidermal growth factor receptor erbB1	6.3	6.3	6.3	pKi	1
Homo sapiens	Epithelial discoidin domain-containing receptor 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	5.6	5.6	5.6	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6	6	6	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	5.8	5.8	5.8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 3	5.9	5.9	5.9	pKd	4
Homo sapiens	Fibroblast growth factor receptor 3	6.3	6.3	6.3	pKi	1
Homo sapiens	Focal adhesion kinase 1	5.5	5.5	5.5	pKi	1
Homo sapiens	G protein-coupled receptor kinase 5	6	6	6	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 3	5.9	5.9	5.9	pKd	2
Homo sapiens	MAP kinase-activated protein kinase 5	8.1	8.1	8.1	pKd	1
Homo sapiens	MAP kinase signal-integrating kinase 2	7.9	7.9	7.9	pIC50	1
Homo sapiens	Maternal embryonic leucine zipper kinase	6	6	6	pKi	1
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	5.6	5.6	5.6	pKd	2
Homo sapiens	NT-3 growth factor receptor	5.6	5.6	5.6	pKi	1
Homo sapiens	Platelet-derived growth factor receptor alpha	6.1	6.1	6.1	pIC50	1
Homo sapiens	Protein tyrosine kinase 2 beta	5.7	5.7	5.7	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	6.1	6.1	6.1	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	5.5	5.5	5.5	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	6.1	6.1	6.1	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase 10	5.4	5.4	5.4	pKd	2
Mus musculus	Serine/threonine-protein kinase 12	6.8	6.8	6.8	pIC50	3
Homo sapiens	Serine/threonine-protein kinase 17A	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase 17B	8.1	8.1	8.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.5	6.5	9	pIC50	10
Homo sapiens	Serine/threonine-protein kinase Aurora-A	8.7	8.2	9.5	pKd	7
Mus musculus	Serine/threonine-protein kinase Aurora-A	8.4	7.5	8.4	pIC50	4
Mus musculus	Serine/threonine-protein kinase Aurora-A	8.2	8.2	8.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.4	5.2	8	pIC50	7
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.4	7.4	7.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-C	7.6	7.6	7.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase Chk2	4.6	4.6	4.6	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Chk2	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK 1	5	5	5	pKi	1
Homo sapiens	Serine/threonine-protein kinase PLK1	4.3	4.3	4.3	pIC50	1
Homo sapiens	Serine/threonine-protein kinase PLK3	5.2	5.2	5.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase PLK4	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK1	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase ABL	6.1	5.4	6.4	pKd	18
Homo sapiens	Tyrosine-protein kinase ABL	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL2	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	7.2	7.2	7.2	pKd	3
Homo sapiens	Tyrosine-protein kinase BLK	7.1	7.1	7.1	pKi	1
Homo sapiens	Tyrosine-protein kinase BMX	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase BTK	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase BTK	5.6	5.6	5.6	pKi	1
Homo sapiens	Tyrosine-protein kinase CSK	5.1	5.1	5.1	pKd	2
Homo sapiens	Tyrosine-protein kinase FER	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase FGR	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	5.9	5.9	5.9	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	6.2	6.2	6.2	pKi	1
Homo sapiens	Tyrosine-protein kinase LCK	5.5	5.5	5.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase LCK	6.2	6.2	6.2	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	5.9	5.9	5.9	pKd	2
Homo sapiens	Tyrosine-protein kinase Lyn	6.6	6.6	6.6	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	5	5	5	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	6.9	6.9	6.9	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.4	6.4	6.4	pKd	2
Homo sapiens	Tyrosine-protein kinase SRC	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase SRC	5.8	5.8	5.8	pKi	1
Homo sapiens	Tyrosine-protein kinase TEC	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase TIE-2	6.5	6.5	6.5	pKd	2
Homo sapiens	Tyrosine-protein kinase YES	6.6	6.6	6.6	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	6	6	6	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	6.1	6.1	6.1	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	5.5	5.5	5.5	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 3	6.3	6.3	6.3	pKi	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
137

2 P
138

3 L
139

4 G
140

5 K
141

6 G
142

7 K
143

8 F
144

9 G
145

10 N
146

11 V
147

12 Y
148

13 L
149

14 L
159

15 A
160

16 L
161

17 K
162

18 V
163

19 L
164

20 Q
177

•

αC

b.l

21 L
178

22 R
179

23 R
180

24 E
181

25 V
182

26 E
183

27 I
184

28 Q
185

29 S
186

30 H
187

31 L
188

32 R
189

33 P
191

34 N
192

35 I
193

36 L
194

37 R
195

38 L
196

39 Y
197

40 G
198

•

hinge

linker

αD

αE

41 Y
199

42 Y
207

43 L
208

44 I
209

45 L
210

46 E
211

47 Y
212

48 A
213

49 P
214

50 R
215

51 G
216

52 E
217

53 V
218

54 Y
219

55 K
220

56 E
221

57 L
222

58 Q
223

59 K
224

60 Y
246

•

••

•••

•

αE

c.l

VII

VIII

61 C
247

62 H
248

63 S
249

64 K
250

65 R
251

66 V
252

67 I
253

68 H
254

69 R
255

70 D
256

71 I
257

72 K
258

73 P
259

74 E
260

75 N
261

76 L
262

77 L
263

78 L
264

79 I
272

80 A
273

•

DFG

a.l

81 D
274

82 F
275

83 G
276

84 W
277

85 S
278

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: