Version: 3.2
Updated: 29-Oct-2025
Mitogen-activated protein kinase kinase kinase 14
Kinase structure
Kinase:MAP3K14 (NIK)
Family:STE-Unique
Group:STE
Species:HUMAN
IUPHAR/BPS ID:2074
PDB:4G3D
sc-PDB:
KIDFamMap:Search
Release date:2012-08-15
PubMed: 22921830
Chain:B
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The orthosteric binding pocket


More entries for 4G3D
4G3DChain: A
4G3DChain: D
4G3DChain: E


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):53.8° (15.3Å)
G-rich loop rotation:112°
Quality Score:6.8
Resolution:2.9 Å
Missing Residues:3
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I8
Ligand
No
Protein
No

Pocket alignment
Uniprot sequence:LRLGRGSFGEVHRCAVKKVFRAEELMACAGLTPRIVPLYGANIFMELLEGGSLGQLVKEYLHSRRILHGDVKADNVLLLCDFGHA
Sequence structure:___GRGSFGEVHRCAVKKVFRAEELMACAGLTPRIVPLYGANIFMELLEGGSLGQLVKEYLHSRRILHGDVKADNVLLLCDFGHA