KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Calcium/calmodulin-dependent protein kinase II alpha

Kinase structure
Kinase:	CAMK2A (CaMK2a)
Family:	CAMK2
Group:	CAMK
Species:	HUMAN
IUPHAR/BPS ID:	1555
PDB:	3SOA
sc-PDB:
KIDFamMap:	Search
Release date:	2011-08-31
PubMed:	21884935
Chain:	A
Orthosteric ligand:	DB8

Structural information
DFG conformation:	out-like
αC-helix conformation:	in
G-rich loop angle (distance):	61.5° (18.8Å)
G-rich loop rotation:	60.2°
Quality Score:	7.2
Resolution:	3.55 Å
Missing Residues:	2
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front

Pocket alignment
Uniprot sequence:	EELGKGAFSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLIFDLVTGGELFEDIVAHCHQMGVVHRDLKPENLLLLADFGLA
Sequence structure:	EELGKG__SVVRRYAAMIIKLEREARICRLLKPNIVRLHDSYLIFDLVTGGELFEDIVAHCHQMGVVHRNLKPENLLLLADFGLA

Ligand affinity
ChEMBL ID:	CHEMBL288441
Bioaffinities:	348 records for 195 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Adaptor-associated kinase	5.6	5.6	5.6	pKd	1
Homo sapiens	ALK tyrosine kinase receptor	6.2	6.2	6.2	pKd	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	5.4	5.4	5.4	pKd	1
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	5.7	5.7	5.7	pKd	1
Homo sapiens	BMP-2-inducible protein kinase	6.5	6.5	6.5	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	6.2	6.2	6.2	pKd	1
Homo sapiens	CaM kinase I delta	7	7	7	pIC50	1
Homo sapiens	CaM kinase I delta	6.3	6.3	6.3	pKd	1
Homo sapiens	CaM kinase II alpha	5.4	5.4	5.4	pKd	1
Homo sapiens	CaM kinase II gamma	6.7	6.7	6.7	pIC50	1
Homo sapiens	CaM kinase II gamma	5.4	5.4	5.4	pKd	1
Homo sapiens	CaM-kinase kinase beta	6.1	6.1	6.1	pKd	1
Homo sapiens	Casein kinase I alpha	6.6	6.6	6.6	pKd	1
Homo sapiens	Casein kinase I delta	6.6	6.6	6.6	pKd	1
Homo sapiens	Casein kinase I epsilon	7	7	7	pKd	1
Homo sapiens	Casein kinase I isoform alpha-like	5.6	5.6	5.6	pKd	1
Homo sapiens	Citron Rho-interacting kinase	5.6	5.6	5.6	pKd	1
Homo sapiens	Cyclin-dependent kinase 7	5.9	5.9	5.9	pKd	1
Homo sapiens	Discoidin domain-containing receptor 2	6.9	6.9	6.9	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	9	9	9	pIC50	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	7.7	7.7	7.7	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	8	8	8	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	5.6	5.6	5.6	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	5.6	5.6	5.6	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	8.1	8.1	8.1	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	5.9	5.9	5.9	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 7	5.3	5.3	5.3	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	5.8	5.8	5.8	pKd	2
Homo sapiens	Dual specificity protein kinase CLK3	6.5	6.5	6.5	pKd	2
Homo sapiens	Dual specificity protein kinase CLK4	5.5	5.5	5.5	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	6.2	6.2	6.2	pKd	2
Homo sapiens	Ephrin type-A receptor 1	5.6	5.6	5.6	pKd	1
Homo sapiens	Ephrin type-A receptor 2	7.8	7.8	7.8	pKd	1
Homo sapiens	Ephrin type-A receptor 3	8.2	8.2	8.2	pKd	1
Homo sapiens	Ephrin type-A receptor 4	7.8	7.8	7.8	pKd	1
Homo sapiens	Ephrin type-A receptor 5	7.6	7.6	7.6	pKd	1
Homo sapiens	Ephrin type-A receptor 6	6	6	6	pKd	1
Homo sapiens	Ephrin type-A receptor 8	8.1	8.1	8.1	pKd	1
Homo sapiens	Ephrin type-B receptor 1	7.5	7.5	7.5	pKd	1
Homo sapiens	Ephrin type-B receptor 2	8.1	8.1	8.1	pIC50	1
Homo sapiens	Ephrin type-B receptor 2	8.1	8.1	8.1	pKd	1
Homo sapiens	Ephrin type-B receptor 3	6.7	6.7	6.7	pKd	1
Homo sapiens	Ephrin type-B receptor 4	8.3	8.3	8.3	pIC50	1
Homo sapiens	Ephrin type-B receptor 4	8	8	8	pKd	1
Homo sapiens	Epidermal growth factor receptor erbB1	7.3	7.3	7.3	pIC50	1
Homo sapiens	Epidermal growth factor receptor erbB1	7.4	6.4	7.8	pKd	12
Homo sapiens	Epithelial discoidin domain-containing receptor 1	6.9	6.9	6.9	pKd	1
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	6.6	6.6	6.6	pKd	1
Homo sapiens	Focal adhesion kinase 1	6.3	6.3	6.3	pIC50	1
Homo sapiens	Focal adhesion kinase 1	6.2	6.2	6.2	pKd	2
Homo sapiens	G protein-coupled receptor kinase 4	5.3	5.3	5.3	pKd	1
Homo sapiens	G protein-coupled receptor kinase 7	5.8	5.8	5.8	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	5.5	5.2	5.7	pKd	3
Homo sapiens	Homeodomain-interacting protein kinase 1	6.3	6.3	6.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 3	5.5	5.5	5.5	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 4	6.9	6.9	6.9	pKd	1
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	5.3	5.3	5.3	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	7.3	7.3	7.3	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	6.2	6.2	6.2	pIC50	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	6.4	6.4	6.4	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	6.1	6.1	6.3	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	5.5	5.5	5.5	pKd	1
Homo sapiens	Macrophage colony stimulating factor receptor	6.4	6.4	6.4	pKd	1
Homo sapiens	Macrophage-stimulating protein receptor	5.2	5.2	5.2	pKd	1
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	6.5	6.5	6.5	pKd	1
Homo sapiens	Misshapen-like kinase 1	7.7	7.7	7.7	pIC50	1
Homo sapiens	Misshapen-like kinase 1	8.5	8.5	8.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase 7	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 1	5.4	5.4	5.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	6.2	6.2	6.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	6.3	6.3	6.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	7.5	7.5	7.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	7.3	7.3	7.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	7	7	7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	7	7	7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	7.8	7.8	7.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	8	8	8	pIC50	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	8.5	8.5	8.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	8.3	8.3	8.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	8.1	8.1	8.1	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	9.5	9.5	9.5	pIC50	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	9.3	9.3	9.3	pKd	1
Homo sapiens	Mixed lineage kinase 7	7.1	7.1	7.1	pKd	1
Homo sapiens	Myosin IIIA	5.2	5.2	5.2	pKd	1
Homo sapiens	Myosin-IIIB	5.6	5.6	5.6	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	6.3	6.3	6.3	pKd	1
Homo sapiens	Myotonin-protein kinase	7	7	7	pKd	1
Homo sapiens	Nerve growth factor receptor Trk-A	7.7	7.7	7.7	pIC50	1
Homo sapiens	Nerve growth factor receptor Trk-A	5.5	5.5	5.5	pKd	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	7.6	7.6	7.6	pIC50	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	5.9	5.9	5.9	pKd	1
Homo sapiens	NT-3 growth factor receptor	5.5	5.5	5.5	pKd	1
Homo sapiens	NUAK family SNF1-like kinase 1	5.2	5.2	5.2	pKd	1
Homo sapiens	NUAK family SNF1-like kinase 2	6.7	6.7	6.7	pKd	1
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	5.5	5.5	5.5	pKd	1
Homo sapiens	Phosphorylase kinase gamma subunit 1	6.5	6.5	6.5	pKd	1
Homo sapiens	Phosphorylase kinase gamma subunit 2	5.9	5.9	5.9	pKd	1
Homo sapiens	Platelet-derived growth factor receptor alpha	5.3	5.3	5.3	pKd	1
Homo sapiens	Platelet-derived growth factor receptor beta	6.7	6.7	6.7	pKd	1
Homo sapiens	Protein kinase C delta	5.8	5.8	5.8	pKd	1
Homo sapiens	Protein kinase C epsilon	5.6	5.6	5.6	pKd	1
Homo sapiens	Protein kinase C nu	5.3	5.3	5.3	pKd	1
Homo sapiens	Protein kinase C theta	6	6	6	pKd	1
Homo sapiens	Protein kinase N1	5.5	5.5	5.5	pKd	1
Homo sapiens	Protein kinase N2	5.5	5.5	5.5	pKd	1
Homo sapiens	Protein tyrosine kinase 2 beta	6.9	6.9	6.9	pIC50	1
Homo sapiens	Protein tyrosine kinase 2 beta	6.4	6.4	6.4	pKd	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	7	7	7	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	5.6	5.6	5.6	pIC50	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	5.6	5.6	5.6	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	7.6	7.6	7.6	pKd	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	9.1	9.1	9.1	pKd	1
Homo sapiens	Rho-associated protein kinase 1	6.1	6.1	6.1	pKd	1
Homo sapiens	Rho-associated protein kinase 2	6.4	6.4	6.4	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Ribosomal protein S6 kinase alpha 2	5.5	5.5	5.5	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 3	5.9	5.9	5.9	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase 10	7.3	7.3	7.3	pIC50	1
Homo sapiens	Serine/threonine-protein kinase 10	8.2	8.2	8.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase 2	8.3	8.3	8.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase 24	8.4	8.4	8.4	pIC50	1
Homo sapiens	Serine/threonine-protein kinase 24	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase 25	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase 32A	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 33	7.4	7.4	7.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase 35	8.7	8.7	8.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase 36	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase Chk1	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Chk2	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase DCLK3	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase GAK	8.9	8.9	8.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST1	6.7	6.7	6.7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase MST1	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST2	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	7.4	7.4	7.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek11	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase NEK2	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase NIM1	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine protein kinase NLK	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 1	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 3	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-2	5.8	5.8	5.8	pKd	1
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK1	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK2	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIPK2	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	7.5	7.5	7.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	7.5	7.5	7.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK3	7.2	7.2	7.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase SRPK3	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO2	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	6.3	6.3	6.3	pIC50	1
Homo sapiens	Serine/threonine-protein kinase TBK1	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK2	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK3	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	6.3	6.3	7.1	pKd	2
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.8	7.8	7.8	pKd	1
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	5.4	5.4	5.4	pKd	1
Homo sapiens	Stem cell growth factor receptor	6.7	5.2	7.5	pIC50	5
Homo sapiens	Stem cell growth factor receptor	6.6	6.3	7.1	pKd	7
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	5.3	5.3	5.3	pKd	1
Homo sapiens	TRAF2- and NCK-interacting kinase	7.5	7.5	7.5	pKd	1
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.2	6.2	6.9	pIC50	2
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.5	6.5	6.6	pKd	2
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.5	6.5	7.9	pKi	2
Homo sapiens	Tyrosine kinase non-receptor protein 2	8.6	8.6	8.6	pIC50	2
Homo sapiens	Tyrosine kinase non-receptor protein 2	7.5	7.5	7.5	pKd	1
Homo sapiens	Tyrosine-protein kinase ABL	9	6.3	9.3	pIC50	6
Homo sapiens	Tyrosine-protein kinase ABL	10.1	7.7	10.5	pKd	16
Homo sapiens	Tyrosine-protein kinase ABL2	9.3	9.3	9.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase ABL2	8.8	8.8	8.8	pKd	1
Homo sapiens	Tyrosine-protein kinase BLK	8.5	8.5	8.5	pKd	1
Mus musculus	Tyrosine-protein kinase BLK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase BMX	8.1	8.1	9	pIC50	2
Homo sapiens	Tyrosine-protein kinase BMX	6.7	6.7	6.7	pKd	1
Homo sapiens	Tyrosine-protein kinase BTK	8.6	8.6	8.6	pIC50	1
Homo sapiens	Tyrosine-protein kinase BTK	8.3	8.3	8.3	pKd	1
Homo sapiens	Tyrosine-protein kinase CSK	7.2	7.2	7.2	pIC50	1
Homo sapiens	Tyrosine-protein kinase CSK	7.5	7.5	7.5	pKd	1
Homo sapiens	Tyrosine-protein kinase CTK	5.2	5.2	5.2	pKd	1
Homo sapiens	Tyrosine-protein kinase FER	6.3	6.3	6.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase FER	6.4	6.4	6.4	pKd	1
Homo sapiens	Tyrosine-protein kinase FES	6.5	6.5	6.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase FES	6.5	6.5	6.5	pKd	1
Homo sapiens	Tyrosine-protein kinase FGR	9	9	9	pIC50	1
Homo sapiens	Tyrosine-protein kinase FGR	8.2	8.2	8.2	pKd	1
Homo sapiens	Tyrosine-protein kinase FRK	8.7	8.7	8.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase FRK	8.9	8.9	8.9	pKd	1
Homo sapiens	Tyrosine-protein kinase FYN	6.4	6.4	8.7	pIC50	3
Homo sapiens	Tyrosine-protein kinase FYN	8	8	8	pKd	1
Homo sapiens	Tyrosine-protein kinase HCK	8.5	8.5	8.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase HCK	8.5	8.5	8.5	pKd	2
Homo sapiens	Tyrosine-protein kinase ITK/TSK	5.8	5.8	5.8	pKd	1
Homo sapiens	Tyrosine-protein kinase JAK2	6	6	6	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK3	5.9	5.9	5.9	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	8.9	8.9	8.9	pIC50	1
Homo sapiens	Tyrosine-protein kinase LCK	9.2	9.2	9.2	pKd	1
Homo sapiens	Tyrosine-protein kinase Lyn	8.1	8.1	8.1	pIC50	2
Homo sapiens	Tyrosine-protein kinase Lyn	8.4	8.4	8.4	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	5.7	5.5	6	pKd	7
Homo sapiens	Tyrosine-protein kinase receptor RET	5.4	5.3	5.4	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.5	5.5	5.5	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.2	7.2	7.2	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.5	6.3	6.8	pIC50	3
Homo sapiens	Tyrosine-protein kinase receptor UFO	7.3	7.3	7.3	pKd	1
Homo sapiens	Tyrosine-protein kinase SRC	8.4	7	9	pIC50	32
Homo sapiens	Tyrosine-protein kinase SRC	9	9	9	pKd	3
Homo sapiens	Tyrosine-protein kinase Srms	7	7	7	pKd	1
Homo sapiens	Tyrosine-protein kinase SYK	7.3	7.3	7.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase SYK	6.5	6.5	6.5	pKd	1
Homo sapiens	Tyrosine-protein kinase TEC	6.6	6.6	6.6	pIC50	1
Homo sapiens	Tyrosine-protein kinase TEC	5.5	5.5	5.5	pKd	1
Homo sapiens	Tyrosine-protein kinase TIE-2	5.9	5.9	5.9	pIC50	1
Homo sapiens	Tyrosine-protein kinase TIE-2	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase TXK	7.4	7.4	7.4	pIC50	1
Homo sapiens	Tyrosine-protein kinase TXK	7.1	7.1	7.1	pKd	1
Homo sapiens	Tyrosine-protein kinase TYK2	5.2	5.2	5.4	pKd	4
Homo sapiens	Tyrosine-protein kinase YES	9.4	9.4	9.4	pIC50	1
Homo sapiens	Tyrosine-protein kinase YES	8.4	8.4	8.4	pKd	1
Homo sapiens	Tyrosine-protein kinase ZAP-70	5.8	5.8	5.8	pKd	1
Homo sapiens	Wee1-like protein kinase 2	7	7	7	pKd	2

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 E
17

2 E
18

3 L
19

4 G
20

5 K
21

6 G
22

7 _
_

8 _
_

9 S
25

10 V
26

11 V
27

12 R
28

13 R
29

14 Y
39

15 A
40

16 A
41

17 M
42

18 I
43

19 I
44

20 K
56

•

αC

b.l

21 L
57

22 E
58

23 R
59

24 E
60

25 A
61

26 R
62

27 I
63

28 C
64

29 R
65

30 L
66

31 L
67

32 K
68

33 P
70

34 N
71

35 I
72

36 V
73

37 R
74

38 L
75

39 H
76

40 D
77

hinge

linker

αD

αE

41 S
78

42 Y
86

43 L
87

44 I
88

45 F
89

46 D
90

47 L
91

48 V
92

49 T
93

50 G
94

51 G
95

52 E
96

53 L
97

54 F
98

55 E
99

56 D
100

57 I
101

58 V
102

59 A
103

60 H
125

•

αE

c.l

VII

VIII

61 C
126

62 H
127

63 Q
128

64 M
129

65 G
130

66 V
131

67 V
132

68 H
133

69 R
134

70 N
135

71 L
136

72 K
137

73 P
138

74 E
139

75 N
140

76 L
141

77 L
142

78 L
143

79 L
154

80 A
155

DFG

a.l

81 D
156

82 F
157

83 G
158

84 L
159

85 A
160

••

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: