Maternal embryonic leucine zipper kinase
Kinase structure
Kinase:MELK
Family:CAMKL
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2102
PDB:4IXP
sc-PDB:
KIDFamMap:Search
Release date:2013-09-11
PubMed: 23922895
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:out-like
αC-helix conformation:in
G-rich loop angle (distance):53.3° (15.6Å)
G-rich loop rotation:43.7°
Quality Score:8
Resolution:2.75 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I3
O2
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:ETIGTGGFAKVKLVAIKIMRIKTEIEALKNLRQHICQLYHVFMVLEYCPGGELFDYIISYVHSQGYAHRDLKPENLLFLIDFGLC
Sequence structure:ETIGTGGFAKVKLVAIRIMRIKTEIEALKNLRQHICQLYHVFMVLEYCPGGELFDYIISYVHSQGYAHRDLKPENLLFLIAFGLC