PDB-code
Search results (85 entries covering 31 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | MELK | CAMKL | CAMK | 4d2t | B | B | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show |  |
| MELK | CAMKL | CAMK | 6gvx | B | B | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | Show | |
| MELK | CAMKL | CAMK | 5ih9 | A | B | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1h-pyrazol-1-yl)phenyl]piperazine | Human | Show | |
| MELK | CAMKL | CAMK | 5m5a | A | A | k-252a | Human | Show | |
| MELK | CAMKL | CAMK | 5mai | A | A | 3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide | Human | Show | |
| MELK | CAMKL | CAMK | 5twy | B | 2-(benzyloxy)-4-(1h-pyrazol-4-yl)-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | | |
| MELK | CAMKL | CAMK | 4bkz | A | A | n-(3-aminopropyl)-8-[(3-fluorophenyl)amino]-2,4,5,7-tetrahydropyrazolo[3,4-e]indazole-3-carboxamide | Human | Show | |
| MELK | CAMKL | CAMK | 5mah | A | A | ~{n}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4d2w | B | B | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | C | B | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | C | A | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 5iha | A | B | 1-methyl-4-(4-{4-[3-(2-methylpropoxy)pyridin-4-yl]-1h-pyrazol-1-yl}phenyl)piperazine | Human | Show | |
| MELK | CAMKL | CAMK | 4umr | A | 4-fluoro-n-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide | Human | Show | | |
| MELK | CAMKL | CAMK | 6gvx | A | A | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | Show | |
| MELK | CAMKL | CAMK | 5twu | B | - | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2t | B | A | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2t | A | A | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | D | B | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | D | A | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 4d2w | C | A | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 5k00 | A | B | 4-{2-[(3-methoxyphenyl)amino]-4-[(piperidin-4-yl)methoxy]pyrimidin-5-yl}-n-[2-oxo-2-(phenylamino)ethyl]benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4d2w | D | A | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4bl1 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| MELK | CAMKL | CAMK | 5ihc | A | B | 4-[1-(2-fluorophenyl)-1h-pyrazol-4-yl]-3-[(piperidin-4-yl)methoxy]pyridine | Human | Show | |
| MELK | CAMKL | CAMK | 4d2t | D | A | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2v | A | A | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2w | B | A | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 5ih9 | A | A | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1h-pyrazol-1-yl)phenyl]piperazine | Human | Show | |
| MELK | CAMKL | CAMK | 4umu | A | (2-ethoxy-4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}phenyl)methanaminium | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2p | B | A | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 5mai | A | B | 3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | A | A | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | C | B | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 6vxr | A | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | Show | |
| MELK | CAMKL | CAMK | 5k00 | A | A | 4-{2-[(3-methoxyphenyl)amino]-4-[(piperidin-4-yl)methoxy]pyrimidin-5-yl}-n-[2-oxo-2-(phenylamino)ethyl]benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4d2w | A | A | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | C | A | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 4d2v | D | A | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 6vxr | A | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | D | B | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 6gvx | B | A | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | Show | |
| MELK | CAMKL | CAMK | 5twy | A | 2-(benzyloxy)-4-(1h-pyrazol-4-yl)-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2v | B | A | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 4umq | A | A | 3-{5-[(3-hydroxy-5-methoxyphenyl)amino]-2-(phenylcarbamoyl)phenoxy}propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2t | C | A | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 5mah | A | B | ~{n}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4bky | A | A | 3'-{[(4-bromo-1-methyl-1h-pyrrol-2-yl)carbonyl]amino}-n-[(1s)-1-phenyl-2-(pyrrolidin-1-yl)ethyl]-1',4'-dihydro-5'h-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxamide | Human | Show | |
| MELK | CAMKL | CAMK | 5m5a | A | B | k-252a | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | B | B | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 5tx3 | B | 7-[(1s)-4-hydroxy-2,3-dihydro-1h-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6h-pyrrolo[2,3-d]pyrimidin-6-one | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2v | A | B | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 4umq | A | B | 3-{5-[(3-hydroxy-5-methoxyphenyl)amino]-2-(phenylcarbamoyl)phenoxy}propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 5tvt | A | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1h)-one | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2w | C | B | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 6gvx | A | B | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | Show | |
| MELK | CAMKL | CAMK | 5iha | A | A | 1-methyl-4-(4-{4-[3-(2-methylpropoxy)pyridin-4-yl]-1h-pyrazol-1-yl}phenyl)piperazine | Human | Show | |
| MELK | CAMKL | CAMK | 5twl | A | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1h)-one | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2t | A | B | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4bky | A | B | 3'-{[(4-bromo-1-methyl-1h-pyrrol-2-yl)carbonyl]amino}-n-[(1s)-1-phenyl-2-(pyrrolidin-1-yl)ethyl]-1',4'-dihydro-5'h-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxamide | Human | Show | |
| MELK | CAMKL | CAMK | 4d2v | B | B | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 4bkz | A | B | n-(3-aminopropyl)-8-[(3-fluorophenyl)amino]-2,4,5,7-tetrahydropyrazolo[3,4-e]indazole-3-carboxamide | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | A | A | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 5maf | A | methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate | Human | Show | | |
| MELK | CAMKL | CAMK | 5ihc | A | A | 4-[1-(2-fluorophenyl)-1h-pyrazol-4-yl]-3-[(piperidin-4-yl)methoxy]pyridine | Human | Show | |
| MELK | CAMKL | CAMK | 4ixp | A | - | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2w | D | B | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 5ih8 | A | n-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1h-pyrazol-1-yl]benzamide | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2t | C | B | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2w | A | B | 4-bromo-n-(2,3,4,5-tetrahydro-1h-3-benzazepin-7-yl)benzamide | Human | Show | |
| MELK | CAMKL | CAMK | 4ump | A | B | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 5twu | A | - | Human | Show | | |
| MELK | CAMKL | CAMK | 5tx3 | A | 7-[(1s)-4-hydroxy-2,3-dihydro-1h-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6h-pyrrolo[2,3-d]pyrimidin-6-one | Human | Show | | |
| MELK | CAMKL | CAMK | 4bl1 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| MELK | CAMKL | CAMK | 4umt | A | 1-(4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}-2-methoxybenzyl)piperazinediium | Human | Show | | |
| MELK | CAMKL | CAMK | 4ump | B | A | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | Human | Show | |
| MELK | CAMKL | CAMK | 4d2v | C | A | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | A | B | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2t | D | B | 3-[2-(phenylcarbamoyl)-5-(1h-pyrazol-4-yl)phenoxy]propan-1-aminium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | D | A | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 4d2p | B | B | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | Human | Show | |
| MELK | CAMKL | CAMK | 5twz | A | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | | |
| MELK | CAMKL | CAMK | 4d2v | D | B | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 5mag | A | A | pf-3758309 | Human | Show | |
| MELK | CAMKL | CAMK | 4d2v | C | B | 7-{[2-methoxy-4-(1h-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1h-3-benzazepinium | Human | Show | |
| MELK | CAMKL | CAMK | 5mag | A | B | pf-3758309 | Human | Show | |
