Version: 3.2
Updated: 29-Oct-2025
Rho associated coiled-coil containing protein kinase 1
Kinase structure
Kinase:ROCK1
Family:DMPK
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1503
PDB:3NDM
sc-PDB:
KIDFamMap:Search
Release date:2010-12-08
PubMed: 20678931
Chain:A
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The orthosteric binding pocket


More entries for 3NDM
3NDMChain: B
3NDMChain: C
3NDMChain: D


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):54.9° (17.1Å)
G-rich loop rotation:70.9°
Quality Score:8
Resolution:3.3 Å
Missing Residues:0
Missing Atoms:0

Pocket alignment
Uniprot sequence:KVIGRGAFGEVQLYAMKLLFFWEERDIMAFANPWVVQLFYAYMVMEYMPGGDLVNLMSNAIHSMGFIHRDVKPDNMLLLADFGTC
Sequence structure:KVIGRGAFGEVQLYAMKLLFFWEERDIMAFANPWVVQLFYAYMVMEYMPGGDLVNLMSNAIHSMGFIHRDVKPDNMLLLADFGTC