Search results (75 entries covering 27 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	ROCK1	DMPK	AGC	5uzj	A		n-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Human	Show
	ROCK1	DMPK	AGC	5wnf	A	B	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	2etr	B		(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamide	Human	Show
	ROCK1	DMPK	AGC	3d9v	A		(s)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine	Human	Show
	ROCK1	DMPK	AGC	5wnh	B		(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3ncz	D		cis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide	Human	Show
	ROCK1	DMPK	AGC	7s25	A	A	2-[3-(methoxymethyl)phenyl]-n-[4-(1h-pyrazol-4-yl)phenyl]acetamide	Human	Show
	ROCK1	DMPK	AGC	7s26	A		2-[methyl(phenyl)amino]-1-[4-(1h-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydropyridin-1(2h)-yl]ethan-1-one	Human	Show
	ROCK1	DMPK	AGC	5wnf	D	A	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	4w7p	D		n~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine	Human	Show
	ROCK1	DMPK	AGC	5wnf	C	A	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	6e9w	B		n-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide	Human	Show
	ROCK1	DMPK	AGC	5wne	C		3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamide	Human	Show
	ROCK1	DMPK	AGC	4w7p	C		n~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine	Human	Show
	ROCK1	DMPK	AGC	5bml	A		n-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamide	Human	Show
	ROCK1	DMPK	AGC	3ndm	B		(3s,4r)-n-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide	Human	Show
	ROCK1	DMPK	AGC	4yvc	A		2-fluoro-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamide	Human	Show
	ROCK1	DMPK	AGC	5wne	D		3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamide	Human	Show
	ROCK1	DMPK	AGC	5hvu	B		2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	Show
	ROCK1	DMPK	AGC	3d9v	B		(s)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine	Human	Show
	ROCK1	DMPK	AGC	3v8s	A		1-(1h-indazol-5-yl)-3-(2-phenylethyl)urea	Human	Show
	ROCK1	DMPK	AGC	3ncz	A		cis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide	Human	Show
	ROCK1	DMPK	AGC	5kkt	A		2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	Show
	ROCK1	DMPK	AGC	5kks	B		2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	Show
	ROCK1	DMPK	AGC	3tv7	B		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	Show
	ROCK1	DMPK	AGC	6e9w	A		n-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide	Human	Show
	ROCK1	DMPK	AGC	7s25	A	B	2-[3-(methoxymethyl)phenyl]-n-[4-(1h-pyrazol-4-yl)phenyl]acetamide	Human	Show
	ROCK1	DMPK	AGC	2etr	A		(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamide	Human	Show
	ROCK1	DMPK	AGC	2v55	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	ROCK1	DMPK	AGC	4yve	A		2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	Show
	ROCK1	DMPK	AGC	4w7p	B		n~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine	Human	Show
	ROCK1	DMPK	AGC	5wnh	C		(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	5wnf	B	B	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3twj	D		-	Human	Show
	ROCK1	DMPK	AGC	4w7p	A		n~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine	Human	Show
	ROCK1	DMPK	AGC	5wng	A		(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3twj	B		-	Human	Show
	ROCK1	DMPK	AGC	5wne	A		3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamide	Human	Show
	ROCK1	DMPK	AGC	5kks	A		2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	Show
	ROCK1	DMPK	AGC	5wnh	A		(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	5wng	B		(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	5wng	C		(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3v8s	D		1-(1h-indazol-5-yl)-3-(2-phenylethyl)urea	Human	Show
	ROCK1	DMPK	AGC	5hvu	A		2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	Show
	ROCK1	DMPK	AGC	5wnf	D	B	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	5wnf	B	A	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	2etk	A		1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine	Human	Show
	ROCK1	DMPK	AGC	2esm	A		5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	Show
	ROCK1	DMPK	AGC	5wnf	C	B	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3ndm	D		(3s,4r)-n-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3tv7	C		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	Show
	ROCK1	DMPK	AGC	8zh5	A		-	Human	Show
	ROCK1	DMPK	AGC	3twj	A		1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	Show
	ROCK1	DMPK	AGC	4yve	B		2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	Show
	ROCK1	DMPK	AGC	7jou	A		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
	ROCK1	DMPK	AGC	4yvc	B		2-fluoro-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamide	Human	Show
	ROCK1	DMPK	AGC	3v8s	C		1-(1h-indazol-5-yl)-3-(2-phenylethyl)urea	Human	Show
	ROCK1	DMPK	AGC	3ncz	B		cis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide	Human	Show
	ROCK1	DMPK	AGC	5bml	B		n-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamide	Human	Show
	ROCK1	DMPK	AGC	5kkt	B		2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	Show
	ROCK1	DMPK	AGC	3v8s	B		1-(1h-indazol-5-yl)-3-(2-phenylethyl)urea	Human	Show
	ROCK1	DMPK	AGC	3tv7	D		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	Show
	ROCK1	DMPK	AGC	5wne	B		3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamide	Human	Show
	ROCK1	DMPK	AGC	5wnh	D		(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	5wnf	A	A	1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3twj	C		1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	Show
	ROCK1	DMPK	AGC	3ndm	C		(3s,4r)-n-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide	Human	Show
	ROCK1	DMPK	AGC	3ndm	A		-	Human	Show
	ROCK1	DMPK	AGC	2etk	B		1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine	Human	Show
	ROCK1	DMPK	AGC	2esm	B		5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	Show
	ROCK1	DMPK	AGC	3ncz	C		cis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide	Human	Show
	ROCK1	DMPK	AGC	2v55	C		phosphoaminophosphonic acid-adenylate ester	Human	Show
	ROCK1	DMPK	AGC	5wng	D		(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide	Human	Show
	ROCK1	DMPK	AGC	5uzj	B		n-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Human	Show
	ROCK1	DMPK	AGC	3tv7	A		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam