PDB-code
| Kinase structure | |
| Kinase: | MET |
| Family: | Met |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1815 |
| PDB: | 3U6H |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2012-02-22 |
| PubMed: | 22320343 |
| Chain: | A |
| (Alternate) Model: | B |
| Orthosteric ligand: | 03X |
 | |
| More entries for 3U6H | |||||
| 3U6H | Alternative model: | A | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | out |
| G-rich loop angle (distance): | 55.5° (16.7Å) |
| G-rich loop rotation: | 11.5° |
| Quality Score: | 7.2 |
| Resolution: | 2 Å |
| Missing Residues: | 2 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front gate back | BP-I-A BP-I-B BP-II-in BP-II-B-in | Cluster I1 I10 | Ligand No No | Protein Yes Yes |
| Pocket alignment | |
| Uniprot sequence: | EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFGLA |
| Sequence structure: | EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNYLASKKFVHRDLAARNCMLVADFG__ |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL2031893 |
| Bioaffinities: | 45 records for 28 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 4 | 4 | 4 | pIC50 | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 4 | 4 | 4 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6 | 6 | 6 | pIC50 | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 8 | 7.7 | 9 | pIC50 | 6 |
| Homo sapiens | Hepatocyte growth factor receptor | 9 | 9 | 9 | pKi | 2 |
| Homo sapiens | Insulin-like growth factor I receptor | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 7.5 | 7.5 | 7.5 | pKi | 1 |
| Homo sapiens | Insulin receptor | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 9 | 9 | 9 | pKi | 1 |
| Homo sapiens | MAP kinase ERK1 | 4.6 | 4.6 | 4.6 | pIC50 | 1 |
| Homo sapiens | MAP kinase p38 alpha | 6 | 6 | 6 | pIC50 | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 6 | 6 | 6 | pIC50 | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 5 | 5 | 5 | 5 | pIC50 | 2 |
| Homo sapiens | Serine/threonine-protein kinase AKT | 5 | 5 | 5 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase AKT2 | 4.6 | 4.6 | 4.6 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 6 | 6 | 6 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 5 | 5 | 5 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase PIM1 | 4.6 | 4.6 | 4.6 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase PIM2 | 4.6 | 4.6 | 4.6 | pIC50 | 1 |
| Homo sapiens | Stem cell growth factor receptor | 7 | 7 | 7 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 5 | 5 | 5 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 6 | 6 | 6 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 5 | 5 | 5 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 7 | 7 | 7 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.1 | 8 | 8.1 | pIC50 | 4 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.1 | 8.1 | 8.1 | pKi | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 1082 | 2 V 1083 | 3 I 1084 | 4 G 1085 | 5 R 1086 | 6 G 1087 | 7 H 1088 | 8 F 1089 | 9 G 1090 | 10 C 1091 | 11 V 1092 | 12 Y 1093 | 13 H 1094 | 14 C 1107 | 15 A 1108 | 16 V 1109 | 17 K 1110 | 18 S 1111 | 19 L 1112 | 20 Q 1123 |
| • | • | •• | • | • | • | ||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 1124 | 22 L 1125 | 23 T 1126 | 24 E 1127 | 25 G 1128 | 26 I 1129 | 27 I 1130 | 28 M 1131 | 29 K 1132 | 30 D 1133 | 31 F 1134 | 32 S 1135 | 33 P 1137 | 34 N 1138 | 35 V 1139 | 36 L 1140 | 37 S 1141 | 38 L 1142 | 39 L 1143 | 40 G 1144 |
| •• | • | • | • | • | • | ||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 1145 | 42 L 1154 | 43 V 1155 | 44 V 1156 | 45 L 1157 | 46 P 1158 | 47 Y 1159 | 48 M 1160 | 49 K 1161 | 50 H 1162 | 51 G 1163 | 52 D 1164 | 53 L 1165 | 54 R 1166 | 55 N 1167 | 56 F 1168 | 57 I 1169 | 58 R 1170 | 59 N 1171 | 60 Y 1194 |
| • | • | • | • | • | •• | • | • | ||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 1195 | 62 A 1196 | 63 S 1197 | 64 K 1198 | 65 K 1199 | 66 F 1200 | 67 V 1201 | 68 H 1202 | 69 R 1203 | 70 D 1204 | 71 L 1205 | 72 A 1206 | 73 A 1207 | 74 R 1208 | 75 N 1209 | 76 C 1210 | 77 M 1211 | 78 L 1212 | 79 V 1220 | 80 A 1221 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 1222 | 82 F 1223 | 83 G 1224 | 84 _ _ | 85 _ _ | |||||||||||||||
| •• | • | ||||||||||||||||||
Interaction pattern search
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