Version: 3.2
Updated: 29-Oct-2025
3-phosphoinositide dependent protein kinase 1
Kinase structure
Kinase:PDPK1 (PDK1)
Family:PDK1
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1519
PDB:3ORX
sc-PDB:
KIDFamMap:Search
Release date:2011-03-23
PubMed: 21430264
Chain:D
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The orthosteric binding pocket


More entries for 3ORX
3ORXChain: A
3ORXChain: B
3ORXChain: C
3ORXChain: E
3ORXChain: F
3ORXChain: G
3ORXChain: H


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):56.1° (16.6Å)
G-rich loop rotation:55.8°
Quality Score:9.6
Resolution:2.2 Å
Missing Residues:0
Missing Atoms:4
Ligand binding mode
Waters
Cluster
I1
I3
I4
I6
I8
I9
I11
Ligand
No
No
No
No
No
No
No
Protein
Yes
No
Yes
No
Yes
No
Yes

Allosteric Ligand
Allosteric ligand:1F8
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:KILGEGSFSTVVLYAIKILYVTRERDVMSRLDPFFVKLYFTYFGLSYAKNGELLKYIRKYLHGKGIIHRDLKPENILLITDFGTA
Sequence structure:KILGEGSFSTVVLYAIKILYVTRERDVMSRLDPFFVKLYFCYFGLSYAKNGELLKYIRKYLHGKGIIHRDLKPENILLITDFGTA