KLIFS - the kinase structures database

Version: 3.2
Updated: 01-Nov-2025

Discoidin domain receptor tyrosine kinase 1

Kinase structure
Kinase:	DDR1
Family:	DDR
Group:	TK
Species:	HUMAN
IUPHAR/BPS ID:	1843
PDB:	5BVW
sc-PDB:
KIDFamMap:	Search
Release date:	2015-08-05
PubMed:	26191369
Chain:	A
Orthosteric ligand:	1N1

Structural information
DFG conformation:	out
αC-helix conformation:	in
G-rich loop angle (distance):	58.5° (18Å)
G-rich loop rotation:	55.9°
Quality Score:	6.4
Resolution:	1.94 Å
Missing Residues:	2
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front gate back	BP-I-A BP-I-B	Cluster I1 I4 O1	Ligand No No No	Protein Yes Yes Yes

Pocket alignment
Uniprot sequence:	EKLGEGQFGEVHLVAVKILDFLKEVKIMSRLKPNIIRLLGVCMITDYMENGDLNQFLSAYLATLNFVHRDLATRNCLVIADFGMS
Sequence structure:	EKLGEGQFGEVHLVAVKILDFLKEVKIMSRLKPNIIRLLGVCMITDYMENGDLNQFLSAYLATLNFVHRDLATRNCLVIADFG__

Ligand affinity
ChEMBL ID:	CHEMBL1421
Bioaffinities:	404 records for 131 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Activin receptor type-1	6.2	6.2	6.2	pKd	2
Homo sapiens	Activin receptor type-1	7.1	7.1	7.1	pKi	1
Homo sapiens	Activin receptor type-1B	6.5	6.5	6.5	pKd	2
Homo sapiens	Activin receptor type-2A	6.7	6.7	6.7	pKd	2
Homo sapiens	Activin receptor type-2B	6.2	6.2	6.2	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-1A	5.2	5.2	5.2	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-1B	7.3	7.3	7.3	pKd	1
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Casein kinase I epsilon	5.8	5.8	5.8	pKd	2
Homo sapiens	Chaperone activity of bc1 complex-like, mitochondrial	6.7	6.7	6.7	pKd	2
Homo sapiens	Discoidin domain-containing receptor 2	8.7	6.1	9.4	pIC50	5
Homo sapiens	Discoidin domain-containing receptor 2	8.5	7.8	8.5	pKd	4
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6	6	6	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.2	6.2	6.2	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.9	5.9	5.9	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.8	5.8	5.8	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	8.5	8.5	8.5	pKd	1
Homo sapiens	Dual specificity testis-specific protein kinase 1	7.5	7.5	7.5	pKd	2
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 3	5.9	5.9	5.9	pKi	1
Homo sapiens	Ephrin type-A receptor 1	8.4	8.4	8.4	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.9	6.9	6.9	pIC50	1
Homo sapiens	Ephrin type-A receptor 2	9.1	9.1	9.1	pKd	2
Homo sapiens	Ephrin type-A receptor 2	8.4	8.4	8.4	pKi	1
Homo sapiens	Ephrin type-A receptor 3	10	10	10	pKd	2
Homo sapiens	Ephrin type-A receptor 4	8.9	8.9	8.9	pKd	2
Homo sapiens	Ephrin type-A receptor 5	9.6	9.6	9.6	pKd	2
Homo sapiens	Ephrin type-A receptor 6	5.7	5.7	5.7	pKd	1
Homo sapiens	Ephrin type-A receptor 8	9.6	9.6	9.6	pKd	2
Homo sapiens	Ephrin type-B receptor 1	9.4	9.4	9.4	pKd	2
Homo sapiens	Ephrin type-B receptor 2	8.4	8.4	8.4	pIC50	1
Homo sapiens	Ephrin type-B receptor 2	9.4	9.4	9.4	pKd	2
Homo sapiens	Ephrin type-B receptor 3	8.2	8.2	8.2	pKd	2
Homo sapiens	Ephrin type-B receptor 4	9.5	9.5	9.5	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	6.8	5.5	7.7	pIC50	5
Homo sapiens	Epidermal growth factor receptor erbB1	6.9	5.6	7.1	pKd	22
Homo sapiens	Epithelial discoidin domain-containing receptor 1	8.3	8.3	9.3	pIC50	2
Homo sapiens	Epithelial discoidin domain-containing receptor 1	9.2	9.2	9.2	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	5.8	5.8	5.8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6.1	6.1	6.1	pIC50	1
Homo sapiens	Fibroblast growth factor receptor 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	5.9	5.9	5.9	pKd	2
Homo sapiens	Fibroblast growth factor receptor 3	5.4	5.4	5.4	pKd	1
Homo sapiens	Fibroblast growth factor receptor 3	5.9	5.9	5.9	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	5.3	5.3	5.3	pKi	1
Homo sapiens	LIM domain kinase 1	6.9	6.9	6.9	pIC50	1
Homo sapiens	LIM domain kinase 1	6.2	6.2	6.2	pKd	2
Homo sapiens	LIM domain kinase 1	6.6	6.6	6.6	pKi	1
Homo sapiens	LIM domain kinase 2	7.1	7.1	7.1	pKd	2
Homo sapiens	Macrophage colony stimulating factor receptor	8.1	8.1	8.3	pIC50	2
Homo sapiens	Macrophage colony stimulating factor receptor	9.2	9.2	9.2	pKd	2
Homo sapiens	MAP kinase p38 alpha	7.6	6.3	7.6	pKd	5
Homo sapiens	MAP kinase p38 alpha	7.5	7.5	7.5	pKi	1
Homo sapiens	MAP kinase p38 beta	6.4	6.4	6.4	pKd	2
Homo sapiens	Misshapen-like kinase 1	6.4	6.4	6.4	pKd	1
Homo sapiens	Misshapen-like kinase 1	6.1	6.1	6.1	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	5.6	5.6	5.6	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	5.3	5.3	5.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	6.9	6.9	6.9	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	6.6	6.6	6.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	6.5	6.5	6.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	5.4	5.4	5.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	6	6	6	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.9	5.9	5.9	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.2	6.2	6.2	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	5.5	5.5	5.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.4	7.4	7.4	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.8	7.8	7.8	pKi	1
Homo sapiens	Mixed lineage kinase 7	7.4	7.4	7.4	pKd	2
Homo sapiens	Mixed lineage kinase 7	7.3	7.3	7.3	pKi	1
Homo sapiens	myosin light chain kinase 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Myotonin-protein kinase	5.9	5.9	5.9	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	7.2	7.2	8	pIC50	2
Homo sapiens	Platelet-derived growth factor receptor alpha	9.3	9.3	9.3	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	8	8	8	pKi	1
Homo sapiens	Platelet-derived growth factor receptor beta	7.6	7.6	7.6	pIC50	1
Homo sapiens	Platelet-derived growth factor receptor beta	9.2	9.2	9.2	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.9	8.9	8.9	pKi	1
Homo sapiens	Protein kinase N2	5.3	5.3	5.3	pKi	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	6.2	6.2	6.2	pIC50	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	5.9	5.9	5.9	pKd	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	6.8	6.8	6.8	pKi	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	7.3	7.3	7.3	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	7.4	7.4	7.4	pKi	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	7.8	7.8	7.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 10	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase 25	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase 35	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase 36	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.6	5.6	5.6	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5	5	5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.2	5.2	5.2	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase B-raf	6.2	6.2	6.3	pKd	4
Homo sapiens	Serine/threonine-protein kinase GAK	8.6	8.6	8.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.2	5.2	5.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase MRCK beta	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST1	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase mTOR	4.5	4.5	4.5	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Nek11	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase NEK2	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine protein kinase NLK	6.6	6.6	6.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase RAF	6.8	6.8	6.8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase RAF	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase receptor R3	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIPK2	7	7	7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase RIPK2	7.5	7.5	7.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase SBK1	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	8.4	8.4	8.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	8.2	8.2	8.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	9.1	9.1	9.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase SIK3	7.6	7.6	7.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	6	6	6	pKi	1
Homo sapiens	Serine/threonine-protein kinase TAO2	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	8	8	8	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK3	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	5.2	5.2	5.2	pKd	3
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.1	7.1	7.1	pKd	1
Homo sapiens	Stem cell growth factor receptor	8.3	6.9	8.8	pIC50	9
Homo sapiens	Stem cell growth factor receptor	9.1	8.6	9.2	pKd	13
Homo sapiens	TGF-beta receptor type I	6.6	6.6	6.6	pKd	2
Homo sapiens	TGF-beta receptor type II	5.5	5.5	5.5	pKd	2
Homo sapiens	TRAF2- and NCK-interacting kinase	5.7	5.7	5.7	pKd	2
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.7	6.7	8.2	pIC50	2
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	6.9	6.8	6.9	pKd	3
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	7.1	7.1	9.3	pKi	2
Homo sapiens	Tyrosine kinase non-receptor protein 2	8.3	8.2	8.3	pKd	3
Homo sapiens	Tyrosine kinase non-receptor protein 2	8.6	8.6	8.6	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL	8.5	5.8	9.8	pIC50	14
Homo sapiens	Tyrosine-protein kinase ABL	10.2	6.1	10.8	pKd	22
Homo sapiens	Tyrosine-protein kinase ABL2	9.8	9.8	9.8	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	9.7	9.7	9.7	pKd	2
Mus musculus	Tyrosine-protein kinase BLK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase BMX	8.9	8.9	8.9	pKd	2
Homo sapiens	Tyrosine-protein kinase BRK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase BRK	8.1	8.1	8.1	pKd	2
Homo sapiens	Tyrosine-protein kinase BRK	8.3	8.3	8.3	pKi	1
Homo sapiens	Tyrosine-protein kinase BTK	8.3	8.3	8.9	pIC50	3
Homo sapiens	Tyrosine-protein kinase BTK	8.9	8.9	8.9	pKd	2
Homo sapiens	Tyrosine-protein kinase CSK	9	9	9	pKd	2
Homo sapiens	Tyrosine-protein kinase FES	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase FGR	9.3	9.3	9.3	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	9.5	9.5	9.5	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	9.7	9.7	9.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase FYN	9.1	9.1	9.1	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	9.5	9.5	9.5	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	9.5	9.5	9.5	pKi	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	6.6	6.6	6.6	pIC50	1
Homo sapiens	Tyrosine-protein kinase JAK2	6	6	6	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK2	5.9	5.9	5.9	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	6.2	6.2	6.2	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	8.5	8.4	9.4	pIC50	4
Homo sapiens	Tyrosine-protein kinase LCK	9.7	9.7	9.7	pKd	2
Mus musculus	Tyrosine-protein kinase LCK	10.2	10.2	10.2	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	9.2	9.2	9.2	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor FLT3	5.2	5	5.5	pKd	7
Homo sapiens	Tyrosine-protein kinase receptor RET	5.7	5.7	6.4	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor RET	6.1	5.5	6.4	pKd	5
Homo sapiens	Tyrosine-protein kinase receptor UFO	5.7	5.7	5.7	pKi	1
Gallus gallus	Tyrosine-protein kinase SRC	6.3	6.3	9.4	pIC50	2
Gallus gallus	Tyrosine-protein kinase SRC	8	8	8	pKd	1
Homo sapiens	Tyrosine-protein kinase SRC	9.2	7.9	9.5	pIC50	9
Homo sapiens	Tyrosine-protein kinase SRC	9.7	8	9.7	pKd	4
Homo sapiens	Tyrosine-protein kinase Srms	7.9	7.9	7.9	pKd	2
Homo sapiens	Tyrosine-protein kinase Srms	9.2	9.2	9.2	pKi	1
Homo sapiens	Tyrosine-protein kinase SYK	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase SYK	6.7	6.7	6.7	pKi	1
Homo sapiens	Tyrosine-protein kinase TEC	6.5	6.5	6.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase TEC	7.9	7.9	7.9	pKd	2
Homo sapiens	Tyrosine-protein kinase TXK	9.5	9.5	9.5	pIC50	1
Homo sapiens	Tyrosine-protein kinase TXK	8.7	8.7	8.7	pKd	2
Homo sapiens	Tyrosine-protein kinase TYK2	5.8	5.8	7	pKd	4
Homo sapiens	Tyrosine-protein kinase YES	9.3	9.3	9.3	pIC50	3
Homo sapiens	Tyrosine-protein kinase YES	9.5	9.5	9.5	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	5.3	5.3	5.3	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	5.6	5.6	5.6	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.9	5.9	5.9	pKi	1
Homo sapiens	Wee1-like protein kinase 2	6.3	6.3	6.7	pKd	2

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 E
614

2 K
615

3 L
616

4 G
617

5 E
618

6 G
619

7 Q
620

8 F
621

9 G
622

10 E
623

11 V
624

12 H
625

13 L
626

14 V
652

15 A
653

16 V
654

17 K
655

18 I
656

19 L
657

20 D
668

•

αC

b.l

21 F
669

22 L
670

23 K
671

24 E
672

25 V
673

26 K
674

27 I
675

28 M
676

29 S
677

30 R
678

31 L
679

32 K
680

33 P
682

34 N
683

35 I
684

36 I
685

37 R
686

38 L
687

39 L
688

40 G
689

•

hinge

linker

αD

αE

41 V
690

42 C
698

43 M
699

44 I
700

45 T
701

46 D
702

47 Y
703

48 M
704

49 E
705

50 N
706

51 G
707

52 D
708

53 L
709

54 N
710

55 Q
711

56 F
712

57 L
713

58 S
714

59 A
715

60 Y
756

•

••

•••

•

αE

c.l

VII

VIII

61 L
757

62 A
758

63 T
759

64 L
760

65 N
761

66 F
762

67 V
763

68 H
764

69 R
765

70 D
766

71 L
767

72 A
768

73 T
769

74 R
770

75 N
771

76 C
772

77 L
773

78 V
774

79 I
782

80 A
783

•

DFG

a.l

81 D
784

82 F
785

83 G
786

84 _
_

85 _
_

•

Interaction pattern search

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