Search results (61 entries covering 32 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	DDR1	DDR	TK	5sb0	A		n-{[(1r,2s)-2-{2-[(pyridin-3-yl)oxy]ethyl}cyclohexyl]methyl}-3-(trifluoromethoxy)benzamide	Human	Show
	DDR1	DDR	TK	5sav	A	A	n-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide	Human	Show
	DDR1	DDR	TK	5sb1	A	A	4-chloro-n-[(3s,4r)-4-phenylpyrrolidin-3-yl]-3-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide	Human	Show
	DDR1	DDR	TK	5sav	A	B	n-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide	Human	Show
	DDR1	DDR	TK	4bkj	A	A	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	DDR1	DDR	TK	5bvn	A		n-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide	Human	Show
	DDR1	DDR	TK	5saz	A	B	2-chloro-5-{3-chloro-4-[(2-hydroxyethyl)amino]benzamido}-n-(1h-pyrrolo[2,3-b]pyridin-5-yl)benzamide	Human	Show
	DDR1	DDR	TK	4bkj	B	B	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	DDR1	DDR	TK	6fil	A	A	2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide	Human	Show
	DDR1	DDR	TK	3zos	B	A	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	DDR1	DDR	TK	6fio	A	B	2-[1'-(1~{h}-indazol-5-ylcarbonyl)-4-methyl-2-oxidanylidene-spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide	Human	Show
	DDR1	DDR	TK	3zos	B	B	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	DDR1	DDR	TK	6few	A	B	2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide	Human	Show
	DDR1	DDR	TK	7be6	A	B	5-amino-n-(4-(((2s)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1h-pyrazole-4-carboxamide	Human	Show
	DDR1	DDR	TK	7feh	A	B	n-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide	Human	Show
	DDR1	DDR	TK	3zos	A	A	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	DDR1	DDR	TK	5fdp	A		(4~{s})-4-methyl-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1~{h}-isoquinoline-7-carboxamide	Human	Show
	DDR1	DDR	TK	4bkj	B	A	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	DDR1	DDR	TK	5saw	A	B	2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide	Human	Show
	DDR1	DDR	TK	5fdx	B		3-[(4-methylpiperazin-1-yl)methyl]-~{n}-[(4~{r})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{h}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide	Human	Show
	DDR1	DDR	TK	7bcm	B		~{n}-[[4-[[(2~{s})-4-cyclohexyl-1-[[(3~{s})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide	Human	Show
	DDR1	DDR	TK	6gwr	B	B	3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide	Human	Show
	DDR1	DDR	TK	6hp9	B		(2~{r})-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{h}-indene-5-carboxamide	Human	Show
	DDR1	DDR	TK	6brj	A		cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide	Human	Show
	DDR1	DDR	TK	6fex	A	B	2-[4-bromanyl-2-oxidanylidene-1'-(1~{h}-pyrazolo[4,3-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide	Human	Show
	DDR1	DDR	TK	6fio	A	A	2-[1'-(1~{h}-indazol-5-ylcarbonyl)-4-methyl-2-oxidanylidene-spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide	Human	Show
	DDR1	DDR	TK	6y23	A		-	Human	Show
	DDR1	DDR	TK	6y23	B		-	Human	Show
	DDR1	DDR	TK	5saz	A	A	2-chloro-5-{3-chloro-4-[(2-hydroxyethyl)amino]benzamido}-n-(1h-pyrrolo[2,3-b]pyridin-5-yl)benzamide	Human	Show
	DDR1	DDR	TK	7bcm	A		~{n}-[[4-[[(2~{s})-4-cyclohexyl-1-[[(3~{s})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide	Human	Show
	DDR1	DDR	TK	5say	A		n-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide	Human	Show
	DDR1	DDR	TK	5sb2	A	A	3-chloro-n-[(1r,2s)-2-phenylcyclopropyl]-5-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide	Human	Show
	DDR1	DDR	TK	5bvo	A		n-(5-{(1s)-1-[(5-fluoro-1,3-benzoxazol-2-yl)amino]ethyl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide	Human	Show
	DDR1	DDR	TK	5bvk	A		1-(2-chlorophenyl)-3-(pyridin-3-ylmethyl)urea	Human	Show
	DDR1	DDR	TK	4ckr	A	A	4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide	Human	Show
	DDR1	DDR	TK	5fdx	A		3-[(4-methylpiperazin-1-yl)methyl]-~{n}-[(4~{r})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{h}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide	Human	Show
	DDR1	DDR	TK	5sau	A	A	3-[(6-aminopyridin-3-yl)ethynyl]-n-[3-(trifluoromethyl)phenyl]benzamide	Human	Show
	DDR1	DDR	TK	5bvw	A		n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide	Human	Show
	DDR1	DDR	TK	6gwr	B	A	3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide	Human	Show
	DDR1	DDR	TK	6fin	A	B	3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{h}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Human	Show
	DDR1	DDR	TK	7be6	A	A	5-amino-n-(4-(((2s)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1h-pyrazole-4-carboxamide	Human	Show
	DDR1	DDR	TK	5sb2	A	B	3-chloro-n-[(1r,2s)-2-phenylcyclopropyl]-5-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide	Human	Show
	DDR1	DDR	TK	5sb1	A	B	4-chloro-n-[(3s,4r)-4-phenylpyrrolidin-3-yl]-3-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide	Human	Show
	DDR1	DDR	TK	5sau	A	B	3-[(6-aminopyridin-3-yl)ethynyl]-n-[3-(trifluoromethyl)phenyl]benzamide	Human	Show
	DDR1	DDR	TK	5saw	A	A	2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide	Human	Show
	DDR1	DDR	TK	6gwr	A	B	3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide	Human	Show
	DDR1	DDR	TK	6bsd	A		n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide	Human	Show
	DDR1	DDR	TK	6hp9	A		(2~{r})-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{h}-indene-5-carboxamide	Human	Show
	DDR1	DDR	TK	6fin	A	A	3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{h}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	Human	Show
	DDR1	DDR	TK	5sax	A	A	2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide	Human	Show
	DDR1	DDR	TK	6fil	A	B	2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide	Human	Show
	DDR1	DDR	TK	5sax	A	B	2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide	Human	Show
	DDR1	DDR	TK	7feh	A	A	n-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide	Human	Show
	DDR1	DDR	TK	6gwr	A	A	3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide	Human	Show
	DDR1	DDR	TK	6fex	A	A	2-[4-bromanyl-2-oxidanylidene-1'-(1~{h}-pyrazolo[4,3-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide	Human	Show
	DDR1	DDR	TK	6few	A	A	2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide	Human	Show
	DDR1	DDR	TK	3zos	A	B	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	DDR1	DDR	TK	6y23	C		-	Human	Show
	DDR1	DDR	TK	4ckr	A	B	4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide	Human	Show
	DDR1	DDR	TK	4bkj	A	B	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	DDR1	DDR	TK	6fiq	A		1-(1~{h}-indazol-5-ylcarbonyl)-5'-methoxy-1'-[2-oxidanylidene-2-[(2~{s})-2-(trifluoromethyl)pyrrolidin-1-yl]ethyl]spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-2'-one	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam