KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	TYK2
Family:	JakA
Group:	TK
Species:	HUMAN
IUPHAR/BPS ID:	2269
PDB:	3NZ0
sc-PDB:
KIDFamMap:	Search
Release date:	2010-10-20
PubMed:	21117080
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	IZA

More entries for 3NZ0
3NZ0	Alternative model:	B	Chain:	A

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	45.1° (13.9Å)
G-rich loop rotation:	63.5°
Quality Score:	8
Resolution:	2 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets	Waters
front	FP-I	Cluster I1 I2 I4 I5	Ligand No Yes No Yes	Protein Yes No Yes Yes

Pocket alignment
Uniprot sequence:	RDLGEGHFGKVSLVAVKALGWKQEIDILRTLYEHIIKYKGCQLVMEYVPLGSLRDYLPRYLHAQHYIHRDLAARNVLLIGDFGLA
Sequence structure:	RDLGEGHFGKVSLVAVKALGWKQEIDILRTLYEHIIKYKGCQLVMEYVPLGSLRDYLPRYLHAQHYIHRNLAARNVLLIGDFGLA

Ligand affinity
ChEMBL ID:	CHEMBL21156
Bioaffinities:	86 records for 45 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	ALK tyrosine kinase receptor	6.8	6.8	6.8	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6.8	6.8	6.8	pKi	1
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	6.3	6.3	6.3	pKi	1
Homo sapiens	c-Jun N-terminal kinase 1	7.8	7.8	7.8	pKi	1
Homo sapiens	c-Jun N-terminal kinase 2	7.1	7.1	7.1	pKi	1
Homo sapiens	Cyclin-dependent kinase 2	5.5	5.5	5.5	pIC50	1
Homo sapiens	Death-associated protein kinase 3	9	9	9	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	7	7	7	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	6.4	6.4	6.4	pKi	1
Homo sapiens	Dual specificity protein kinase CLK4	7.1	7.1	7.1	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	6	6	6	pIC50	1
Homo sapiens	Focal adhesion kinase 1	6.1	6.1	6.1	pKi	1
Homo sapiens	G protein-coupled receptor kinase 5	6.4	6.4	6.4	pKi	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase beta subunit	6.5	6.5	6.5	pIC50	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	7	7	7	pKi	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	7.6	7.6	7.6	pKi	1
Homo sapiens	Leukocyte tyrosine kinase receptor	7.6	7.6	7.6	pKi	1
Homo sapiens	Macrophage-stimulating protein receptor	7.5	7.5	7.5	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	6.5	6.5	6.5	pIC50	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.6	5.6	5.6	pKi	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6	6	6	pKi	1
Homo sapiens	NT-3 growth factor receptor	5.5	5.5	5.5	pKi	1
Homo sapiens	Protein kinase C alpha	5.9	5.9	5.9	pIC50	1
Homo sapiens	Protein kinase C nu	7.1	7.1	7.1	pKi	1
Homo sapiens	Protein kinase C theta	6.1	6.1	6.1	pKi	1
Homo sapiens	Rho-associated protein kinase 1	6.3	6.3	6.3	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.4	6.4	6.4	pKi	2
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.3	7.3	7.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase Chk1	5.5	5.5	5.5	pKi	1
Homo sapiens	Serine/threonine-protein kinase PIM1	6.2	6.2	6.2	pKi	1
Homo sapiens	Serine/threonine-protein kinase TBK1	6.7	6.7	6.7	pKi	1
Homo sapiens	Tyrosine kinase non-receptor protein 2	6.9	6.9	6.9	pKi	1
Homo sapiens	Tyrosine-protein kinase CSK	5.7	5.7	5.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase FYN	6.3	6.3	6.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase HCK	5.1	5.1	5.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase JAK1	7.8	6.2	8.4	pIC50	6
Mus musculus	Tyrosine-protein kinase JAK1	7.8	7.8	7.8	pIC50	4
Homo sapiens	Tyrosine-protein kinase JAK2	9	5.9	9	pIC50	10
Homo sapiens	Tyrosine-protein kinase JAK2	8.6	8.6	8.6	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	8.3	6.1	8.3	pIC50	10
Homo sapiens	Tyrosine-protein kinase JAK3	7.4	7.4	7.4	pKi	2
Homo sapiens	Tyrosine-protein kinase receptor RET	6.7	6.7	6.7	pKi	1
Homo sapiens	Tyrosine-protein kinase TIE-2	4.6	4.6	4.6	pIC50	1
Homo sapiens	Tyrosine-protein kinase TYK2	9	5.8	9	pIC50	10
Homo sapiens	Vascular endothelial growth factor receptor 1	5.8	5.8	5.8	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.9	5.9	5.9	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.8	5.8	5.8	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	6.2	6.2	6.2	pIC50	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
901

2 D
902

3 L
903

4 G
904

5 E
905

6 G
906

7 H
907

8 F
908

9 G
909

10 K
910

11 V
911

12 S
912

13 L
913

14 V
927

15 A
928

16 V
929

17 K
930

18 A
931

19 L
932

20 G
943

•

αC

b.l

21 W
944

22 K
945

23 Q
946

24 E
947

25 I
948

26 D
949

27 I
950

28 L
951

29 R
952

30 T
953

31 L
954

32 Y
955

33 E
957

34 H
958

35 I
959

36 I
960

37 K
961

38 Y
962

39 K
963

40 G
964

•

hinge

linker

αD

αE

41 C
965

42 Q
975

43 L
976

44 V
977

45 M
978

46 E
979

47 Y
980

48 V
981

49 P
982

50 L
983

51 G
984

52 S
985

53 L
986

54 R
987

55 D
988

56 Y
989

57 L
990

58 P
991

59 R
992

60 Y
1013

•

••

•

αE

c.l

VII

VIII

61 L
1014

62 H
1015

63 A
1016

64 Q
1017

65 H
1018

66 Y
1019

67 I
1020

68 H
1021

69 R
1022

70 N
1023

71 L
1024

72 A
1025

73 A
1026

74 R
1027

75 N
1028

76 V
1029

77 L
1030

78 L
1031

79 I
1039

80 G
1040

•

DFG

a.l

81 D
1041

82 F
1042

83 G
1043

84 L
1044

85 A
1045

•

Interaction pattern search

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