KLIFS - the kinase structures database

Version: 3.2
Updated: 01-Nov-2025

Kinase structure
Kinase:	RET
Family:	Ret
Group:	TK
Species:	HUMAN
IUPHAR/BPS ID:	2185
PDB:	2IVU
sc-PDB:
KIDFamMap:	Search
Release date:	2006-08-10
PubMed:	16928683
Chain:	A
Orthosteric ligand:	ZD6

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	47.8° (14.8Å)
G-rich loop rotation:	47°
Quality Score:	8
Resolution:	2.5 Å
Missing Residues:	0
Missing Atoms:	26

Ligand binding mode
Pockets	Subpockets	Waters
front gate	BP-I-A BP-I-B	Cluster I1 I5 I10	Ligand Yes No No	Protein Yes Yes Yes

Pocket alignment
Uniprot sequence:	KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS
Sequence structure:	KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS

Ligand affinity
ChEMBL ID:	CHEMBL24828
Bioaffinities:	413 records for 111 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Activin receptor type-1	6.8	6.8	6.8	pKd	2
Homo sapiens	Activin receptor type-1	6.7	6.7	6.7	pKi	1
Homo sapiens	ALK tyrosine kinase receptor	5.7	5.7	5.7	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	5.8	5.8	5.8	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	5	5	5.5	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-1B	6.6	6.6	6.6	pKd	1
Homo sapiens	Casein kinase I epsilon	5.5	5.5	5.8	pKd	3
Homo sapiens	Chaperone activity of bc1 complex-like, mitochondrial	5.4	5.4	5.4	pKd	2
Homo sapiens	Citron Rho-interacting kinase	5.8	5.8	5.8	pKd	2
Homo sapiens	Cyclin-dependent kinase 7	5.4	5.4	5.4	pKd	1
Homo sapiens	Discoidin domain-containing receptor 2	6.5	6.5	6.5	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	5.8	5.8	5.8	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6	6	6	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	6	6	6	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.8	5.8	5.8	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	7.3	7.3	7.3	pKd	1
Homo sapiens	Dual specificity testis-specific protein kinase 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Ephrin type-A receptor 1	6.6	6.6	6.6	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6	5.7	6	pKd	3
Homo sapiens	Ephrin type-A receptor 3	5.7	5.7	5.8	pKd	3
Homo sapiens	Ephrin type-A receptor 4	5.8	5.4	5.8	pKd	3
Homo sapiens	Ephrin type-A receptor 5	6.6	6.5	6.6	pKd	3
Homo sapiens	Ephrin type-A receptor 6	7.3	7.2	7.3	pKd	3
Homo sapiens	Ephrin type-A receptor 7	5.6	5.5	5.6	pKd	3
Homo sapiens	Ephrin type-A receptor 8	7	6.8	7	pKd	3
Homo sapiens	Ephrin type-B receptor 1	6.5	6.3	6.5	pKd	3
Homo sapiens	Ephrin type-B receptor 2	6.4	6.4	6.4	pKd	2
Homo sapiens	Ephrin type-B receptor 4	6.3	5.6	6.3	pKd	3
Homo sapiens	Epidermal growth factor receptor erbB1	6.7	6.1	8	pIC50	11
Homo sapiens	Epidermal growth factor receptor erbB1	8	6.6	8.3	pKd	23
Homo sapiens	Epithelial discoidin domain-containing receptor 1	8	8	8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	5.4	5.2	5.6	pIC50	3
Homo sapiens	Fibroblast growth factor receptor 1	6.3	5.3	6.3	pKd	3
Homo sapiens	Fibroblast growth factor receptor 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	6	5.3	6	pKd	3
Homo sapiens	Fibroblast growth factor receptor 3	5.8	5.2	6.6	pKd	5
Homo sapiens	Fibroblast growth factor receptor 4	5.6	5.6	5.6	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	5.2	5.2	5.4	pKd	3
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	5.4	5.4	5.4	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	5.9	5.9	5.9	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	7.1	7.1	7.1	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	5.7	5.7	5.7	pKi	1
Homo sapiens	Leukocyte tyrosine kinase receptor	6.3	6.3	6.3	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	6.4	6.4	6.4	pKi	1
Homo sapiens	Macrophage colony stimulating factor receptor	5.8	5.8	5.8	pIC50	1
Homo sapiens	Macrophage colony stimulating factor receptor	5.9	5.9	5.9	pKd	2
Homo sapiens	Macrophage-stimulating protein receptor	5.5	5.5	5.5	pIC50	1
Homo sapiens	MAP kinase-interacting serine/threonine-protein kinase MNK1	6.4	6.4	6.4	pKd	2
Homo sapiens	MAP kinase p38 alpha	5.6	5.6	5.6	pKi	1
Homo sapiens	MAP kinase signal-integrating kinase 2	5.8	5.5	5.8	pKd	3
Homo sapiens	Misshapen-like kinase 1	5.5	5.5	5.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase 6	5.8	5.8	5.8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.3	5.3	5.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	5.3	5.3	5.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.8	5.8	5.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	5.8	5.8	5.8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	5.9	5.9	5.9	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.8	6.8	6.8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.4	6.3	6.4	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.5	6.5	6.5	pKi	1
Homo sapiens	Mixed lineage kinase 7	5.3	5.3	5.3	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 1	6	5.2	6	pKd	3
Homo sapiens	Phosphorylase kinase gamma subunit 2	5	5	5.1	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	6.6	6.6	6.6	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	6.8	6.8	6.8	pKi	1
Homo sapiens	Platelet-derived growth factor receptor beta	6	6	6.3	pIC50	2
Homo sapiens	Platelet-derived growth factor receptor beta	7.1	6.6	7.1	pKd	3
Homo sapiens	Platelet-derived growth factor receptor beta	6	6	6	pKi	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	5.9	5.9	5.9	pKd	3
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	6.2	6.2	6.2	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	5.6	5.6	5.6	pKd	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	6.3	6.3	6.3	pKd	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	6.8	6.8	6.8	pKd	1
Homo sapiens	Rho-associated protein kinase 2	5.4	5.4	5.4	pKd	1
Homo sapiens	Rho-associated protein kinase 2	7	7	7	pKi	1
Homo sapiens	Ribosomal protein S6 kinase 1	5.8	5.8	5.8	pKd	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.4	6.4	6.4	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 6	6.6	6.6	6.6	pKd	4
Homo sapiens	Serine/threonine-protein kinase 10	7.1	5.6	7.1	pKd	4
Homo sapiens	Serine/threonine-protein kinase 2	7	7	7	pKd	3
Homo sapiens	Serine/threonine-protein kinase 32A	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase 33	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 35	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.6	5.6	5.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase GAK	7.1	6.5	7.1	pKd	3
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK beta	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	6.2	5.8	6.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase receptor R3	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIPK2	8.3	7.5	8.3	pKd	3
Homo sapiens	Serine/threonine-protein kinase SIK1	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK3	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK3	5.2	5.2	5.2	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	6	6	6	pKd	1
Homo sapiens	Stem cell growth factor receptor	6.5	6.5	6.5	pIC50	1
Homo sapiens	Stem cell growth factor receptor	6.5	5.7	7.5	pKd	16
Homo sapiens	TRAF2- and NCK-interacting kinase	5.6	5.4	5.6	pKd	3
Homo sapiens	Tyrosine-protein kinase ABL	6.8	6.8	7.1	pIC50	2
Homo sapiens	Tyrosine-protein kinase ABL	7.1	6.1	8.1	pKd	29
Homo sapiens	Tyrosine-protein kinase ABL	7.5	7.5	7.5	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL2	7.2	6.9	7.2	pKd	3
Homo sapiens	Tyrosine-protein kinase BLK	7.2	7.2	7.2	pKd	2
Homo sapiens	Tyrosine-protein kinase BRK	6.8	6.8	7.5	pKd	3
Homo sapiens	Tyrosine-protein kinase BTK	5.8	5.8	5.8	pKd	1
Homo sapiens	Tyrosine-protein kinase BTK	5.9	5.9	5.9	pKi	1
Homo sapiens	Tyrosine-protein kinase CSK	5.6	5.4	5.6	pKd	3
Homo sapiens	Tyrosine-protein kinase FGR	6.6	5.7	6.6	pKd	3
Homo sapiens	Tyrosine-protein kinase FRK	6.8	6.3	6.8	pKd	3
Homo sapiens	Tyrosine-protein kinase FYN	6.4	5.2	6.4	pKd	3
Homo sapiens	Tyrosine-protein kinase FYN	6.2	6.2	6.2	pKi	1
Homo sapiens	Tyrosine-protein kinase HCK	6.4	5.4	6.4	pKd	3
Homo sapiens	Tyrosine-protein kinase LCK	7.8	7.2	7.8	pKd	3
Homo sapiens	Tyrosine-protein kinase LCK	7.4	7.4	7.4	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	7	6.2	7	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor FLT3	6.1	5.8	6.7	pKd	13
Homo sapiens	Tyrosine-protein kinase receptor RET	7	6	7.3	pIC50	5
Homo sapiens	Tyrosine-protein kinase receptor RET	7.5	7.5	7.9	pKd	4
Homo sapiens	Tyrosine-protein kinase receptor RET	7.7	7.7	7.7	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7	7	7	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.6	6.6	6.6	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.6	6.6	6.6	pKi	1
Homo sapiens	Tyrosine-protein kinase SRC	6.7	6.7	7.4	pIC50	2
Homo sapiens	Tyrosine-protein kinase SRC	7.2	6.8	7.2	pKd	3
Homo sapiens	Tyrosine-protein kinase Srms	5.7	5.7	5.7	pKd	2
Homo sapiens	Tyrosine-protein kinase TIE-2	5.6	5.6	6.3	pIC50	2
Homo sapiens	Tyrosine-protein kinase TIE-2	6	5.4	6	pKd	3
Homo sapiens	Tyrosine-protein kinase TXK	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase YES	6.9	6.6	6.9	pKd	3
Homo sapiens	Uncharacterized aarF domain-containing protein kinase 4	5.8	5.8	5.8	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7	5.8	7.7	pIC50	8
Homo sapiens	Vascular endothelial growth factor receptor 1	6.6	6.6	6.6	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7.2	7.2	7.2	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.4	5.2	8.1	pIC50	35
Homo sapiens	Vascular endothelial growth factor receptor 2	6.1	6.1	6.3	pKd	3
Homo sapiens	Vascular endothelial growth factor receptor 2	8.2	8.2	8.2	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	6.6	6.6	6.6	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 3	6	6	6.5	pKd	3

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 K
728

2 T
729

3 L
730

4 G
731

5 E
732

6 G
733

7 E
734

8 F
735

9 G
736

10 K
737

11 V
738

12 V
739

13 K
740

14 V
755

15 A
756

16 V
757

17 K
758

18 M
759

19 L
760

20 D
771

•

αC

b.l

21 L
772

22 L
773

23 S
774

24 E
775

25 F
776

26 N
777

27 V
778

28 L
779

29 K
780

30 Q
781

31 V
782

32 N
783

33 P
785

34 H
786

35 V
787

36 I
788

37 K
789

38 L
790

39 Y
791

40 G
792

•

hinge

linker

αD

αE

41 A
793

42 L
801

43 L
802

44 I
803

45 V
804

46 E
805

47 Y
806

48 A
807

49 K
808

50 Y
809

51 G
810

52 S
811

53 L
812

54 R
813

55 G
814

56 F
815

57 L
816

58 R
817

59 E
818

60 Y
864

•

••

•

αE

c.l

VII

VIII

61 L
865

62 A
866

63 E
867

64 M
868

65 K
869

66 L
870

67 V
871

68 H
872

69 R
873

70 D
874

71 L
875

72 A
876

73 A
877

74 R
878

75 N
879

76 I
880

77 L
881

78 V
882

79 I
890

80 S
891

•

DFG

a.l

81 D
892

82 F
893

83 G
894

84 L
895

85 S
896

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: