Version: 3.2
Updated: 24-Dec-2025
Tyrosine kinase, non-receptor, 2
Kinase structure
Kinase:TNK2 (ACK)
Family:Ack
Group:TK
Species:HUMAN
IUPHAR/BPS ID:2246
PDB:4HZS
sc-PDB:
KIDFamMap:Search
Release date:2013-02-06
PubMed: 23342057
Chain:D
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The orthosteric binding pocket


More entries for 4HZS
4HZSChain: A
4HZSChain: B
4HZSChain: C


Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):55.8° (15.8Å)
G-rich loop rotation:52.3°
Quality Score:8
Resolution:3.23 Å
Missing Residues:0
Missing Atoms:0

Pocket alignment
Uniprot sequence:EKLGDGSFGVVRRVAVKCLDFIREVNAMHSLDRNLIRLYGVKMVTELAPLGSLLDRLRKYLESKRFIHRDLAARNLLLIGDFGLM
Sequence structure:EKLGDGSFGVVRRVAVKCLDFIREVNAMHSLDRNLIRLYGVKMVTELAPLGSLLDRLRKYLESKRFIHRDLAARNLLLIGDFGLM