PDB-code
| Kinase structure | |
| Kinase: | STRADA (STLK5) |
| Family: | STE20 |
| Group: | STE |
| Species: | HUMAN |
| PDB: | 3GNI |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2009-06-16 |
| PubMed: | 19513107 |
| Chain: | B |
| Orthosteric ligand: | ATP |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 50.9° (16.2Å) |
| G-rich loop rotation: | 111° |
| Quality Score: | 8 |
| Resolution: | 2.35 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front | FP-II | |||
| Pocket alignment | |
| Uniprot sequence: | TVIGKGFEDLMTVVTVRRIFLQGELHVSKLFNPNIVPYRATWVVTSFMAYGSAKDLICTYIHHMGYVHRSVKASHILILSGLRSN |
| Sequence structure: | TVIGKGFEDLMTVVTVRRIFLQGELHVSKLFNPNIVPYRATWVVTSFMAYGSAKDLICTYIHHMGYVHRSVKASHILILSGLRSN |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL14249 |
| Bioaffinities: | 4 records for 2 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | MAP kinase-activated protein kinase 2 | 5.2 | 4.9 | 5.6 | pIC50 | 3 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 T 73 | 2 V 74 | 3 I 75 | 4 G 76 | 5 K 77 | 6 G 78 | 7 F 79 | 8 E 80 | 9 D 81 | 10 L 82 | 11 M 83 | 12 T 84 | 13 V 85 | 14 V 97 | 15 T 98 | 16 V 99 | 17 R 100 | 18 R 101 | 19 I 102 | 20 F 114 |
| • | • | • | • | • | •• | •• | |||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 115 | 22 Q 116 | 23 G 117 | 24 E 118 | 25 L 119 | 26 H 120 | 27 V 121 | 28 S 122 | 29 K 123 | 30 L 124 | 31 F 125 | 32 N 126 | 33 P 128 | 34 N 129 | 35 I 130 | 36 V 131 | 37 P 132 | 38 Y 133 | 39 R 134 | 40 A 135 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 T 136 | 42 W 144 | 43 V 145 | 44 V 146 | 45 T 147 | 46 S 148 | 47 F 149 | 48 M 150 | 49 A 151 | 50 Y 152 | 51 G 153 | 52 S 154 | 53 A 155 | 54 K 156 | 55 D 157 | 56 L 158 | 57 I 159 | 58 C 160 | 59 T 161 | 60 Y 185 |
| • | • | •• | •• | • | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 I 186 | 62 H 187 | 63 H 188 | 64 M 189 | 65 G 190 | 66 Y 191 | 67 V 192 | 68 H 193 | 69 R 194 | 70 S 195 | 71 V 196 | 72 K 197 | 73 A 198 | 74 S 199 | 75 H 200 | 76 I 201 | 77 L 202 | 78 I 203 | 79 L 211 | 80 S 212 |
| • | • | • | |||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 G 213 | 82 L 214 | 83 R 215 | 84 S 216 | 85 N 217 | |||||||||||||||
| •• | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
