Version: 3.2
Updated: 29-Oct-2025
Death-associated protein kinase 3
Kinase structure
Kinase:DAPK3
Family:DAPK
Group:CAMK
Species:HUMAN
IUPHAR/BPS ID:2004
PDB:2J90
sc-PDB:
KIDFamMap:Search
Release date:2006-11-07
PubMed: 18239682
Chain:B
(Alternate) Model:B
Orthosteric ligand:IZA
2D structure of the orthosteric ligand
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The orthosteric binding pocket


More entries for 2J90
2J90Alternative model: AChain: A
2J90Alternative model: AChain: B
2J90Alternative model: BChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):52.1° (15.6Å)
G-rich loop rotation:52.3°
Quality Score:8.3
Resolution:2 Å
Missing Residues:0
Missing Atoms:17
Ligand binding mode
PocketsSubpocketsWaters
front
Cluster
I4
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:EELGSGQFAIVRKYAAKFIEIEREVNILREIRPNIITLHDIVLILELVSGGELFDFLAEYLHSKRIAHFDLKPENIMLLIDFGIA
Sequence structure:EELGSGQFAIVRKYAAKFIEIEREVNILREIRPNIITLHDIVLILELVSGGELFDFLAEYLHSKRIAHFDLKPENIMLLIDFGIA

Ligand affinity
ChEMBL ID:CHEMBL21156
Bioaffinities: 86 records for 45 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiensALK tyrosine kinase receptor6.86.86.8pKi1
Homo sapiensAMP-activated protein kinase, alpha-1 subunit6.86.86.8pKi1
Homo sapienscAMP-dependent protein kinase alpha-catalytic subunit6.36.36.3pKi1
Homo sapiensc-Jun N-terminal kinase 17.87.87.8pKi1
Homo sapiensc-Jun N-terminal kinase 27.17.17.1pKi1
Homo sapiensCyclin-dependent kinase 25.55.55.5pIC501
Homo sapiensDeath-associated protein kinase 3999pKi1
Homo sapiensDual specificity mitogen-activated protein kinase kinase 1777pKi1
Homo sapiensDual specificity mitogen-activated protein kinase kinase 26.46.46.4pKi1
Homo sapiensDual specificity protein kinase CLK47.17.17.1pKi1
Homo sapiensFibroblast growth factor receptor 2666pIC501
Homo sapiensFocal adhesion kinase 16.16.16.1pKi1
Homo sapiensG protein-coupled receptor kinase 56.46.46.4pKi1
Homo sapiensInhibitor of nuclear factor kappa B kinase beta subunit6.56.56.5pIC501
Homo sapiensInhibitor of nuclear factor kappa B kinase epsilon subunit777pKi1
Homo sapiensLeucine-rich repeat serine/threonine-protein kinase 27.67.67.6pKi1
Homo sapiensLeukocyte tyrosine kinase receptor7.67.67.6pKi1
Homo sapiensMacrophage-stimulating protein receptor7.57.57.5pKi1
Homo sapiensMaternal embryonic leucine zipper kinase6.56.56.5pIC501
Homo sapiensMitogen-activated protein kinase kinase kinase kinase 25.65.65.6pKi1
Homo sapiensNeurotrophic tyrosine kinase receptor type 2666pKi1
Homo sapiensNT-3 growth factor receptor5.55.55.5pKi1
Homo sapiensProtein kinase C alpha5.95.95.9pIC501
Homo sapiensProtein kinase C nu7.17.17.1pKi1
Homo sapiensProtein kinase C theta6.16.16.1pKi1
Homo sapiensRho-associated protein kinase 16.36.36.3pKi1
Homo sapiensRibosomal protein S6 kinase alpha 36.46.46.4pKi2
Homo sapiensSerine/threonine-protein kinase Aurora-B7.37.37.3pKi1
Homo sapiensSerine/threonine-protein kinase Chk15.55.55.5pKi1
Homo sapiensSerine/threonine-protein kinase PIM16.26.26.2pKi1
Homo sapiensSerine/threonine-protein kinase TBK16.76.76.7pKi1
Homo sapiensTyrosine kinase non-receptor protein 26.96.96.9pKi1
Homo sapiensTyrosine-protein kinase CSK5.75.75.7pIC501
Homo sapiensTyrosine-protein kinase FYN6.36.36.3pIC501
Homo sapiensTyrosine-protein kinase HCK5.15.15.1pIC501
Homo sapiensTyrosine-protein kinase JAK17.86.28.4pIC506
Mus musculusTyrosine-protein kinase JAK17.87.87.8pIC504
Homo sapiensTyrosine-protein kinase JAK295.99pIC5010
Homo sapiensTyrosine-protein kinase JAK28.68.68.6pKi2
Homo sapiensTyrosine-protein kinase JAK38.36.18.3pIC5010
Homo sapiensTyrosine-protein kinase JAK37.47.47.4pKi2
Homo sapiensTyrosine-protein kinase receptor RET6.76.76.7pKi1
Homo sapiensTyrosine-protein kinase TIE-24.64.64.6pIC501
Homo sapiensTyrosine-protein kinase TYK295.89pIC5010
Homo sapiensVascular endothelial growth factor receptor 15.85.85.8pIC501
Homo sapiensVascular endothelial growth factor receptor 25.95.95.9pIC501
Homo sapiensVascular endothelial growth factor receptor 25.85.85.8pKi1
Homo sapiensVascular endothelial growth factor receptor 36.26.26.2pIC501


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 E
17		2 E
18		3 L
19		4 G
20		5 S
21		6 G
22		7 Q
23		8 F
24		9 A
25		10 I
26		11 V
27		12 R
28		13 K
29		14 Y
39		15 A
40		16 A
41		17 K
42		18 F
43		19 I
44		20 E
60
••••••
αC b.l IV
21 I
61		22 E
62		23 R
63		24 E
64		25 V
65		26 N
66		27 I
67		28 L
68		29 R
69		30 E
70		31 I
71		32 R
72		33 P
74		34 N
75		35 I
76		36 I
77		37 T
78		38 L
79		39 H
80		40 D
81
•
IV V GK hinge linker αD αE
41 I
82		42 V
90		43 L
91		44 I
92		45 L
93		46 E
94		47 L
95		48 V
96		49 S
97		50 G
98		51 G
99		52 E
100		53 L
101		54 F
102		55 D
103		56 F
104		57 L
105		58 A
106		59 E
107		60 Y
129
•••••
αE VI c.l VII VIII x
61 L
130		62 H
131		63 S
132		64 K
133		65 R
134		66 I
135		67 A
136		68 H
137		69 F
138		70 D
139		71 L
140		72 K
141		73 P
142		74 E
143		75 N
144		76 I
145		77 M
146		78 L
147		79 L
159		80 I
160
••
DFG a.l
81 D
161		82 F
162		83 G
163		84 I
164		85 A
165
•

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