KIT proto-oncogene receptor tyrosine kinase
Kinase structure
Kinase:KIT
Family:PDGFR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1805
PDB:1T45
sc-PDB:
KIDFamMap:Search
Release date:2004-06-15
PubMed: 15123710
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 1T45
1T45Alternative model: AChain: A


Structural information
DFG conformation:out
αC-helix conformation:in
G-rich loop angle (distance):62.7° (18.9Å)
G-rich loop rotation:47.1°
Quality Score:7.2
Resolution:1.9 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I5
I6
I9
Ligand
No
No
No
No
Protein
Yes
Yes
No
Yes

Pocket alignment
Uniprot sequence:KTLGAGAFGKVVEVAVKMLALMSELKVLSYLGMNIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDLAARNILLICDFGLA
Sequence structure:KTLGAGAFGKVVEVAVKMLALMSELKVLSYLGMNIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDLAARNILLICDFGLA