Search results (69 entries covering 35 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	KIT	PDGFR	TK	6kla	A	B	n-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine	Human	Show
	KIT	PDGFR	TK	6mob	A	A	n-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-n'-phenylurea	Human	Show
	KIT	PDGFR	TK	1t46	A	B	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	KIT	PDGFR	TK	6xva	B		~{n}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide	Human	Show
	KIT	PDGFR	TK	6gqm	B		~{n}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	6gql	A		~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	8pqe	A	B	~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]prop-2-enamide	Human	Show
	KIT	PDGFR	TK	6gqk	A	B	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	3g0e	A	B	n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	KIT	PDGFR	TK	6gqk	A	A	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	6hh1	A	A	~{n}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{h}-1,2,4-triazol-3-amine	Human	Show
	KIT	PDGFR	TK	7khk	A		4,5-dimethyl-n-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazole-3-carboxamide	Human	Show
	KIT	PDGFR	TK	1t45	A	A	-	Human	Show
	KIT	PDGFR	TK	6gqj	B	B	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	6xv9	A		~{n}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide	Human	Show
	KIT	PDGFR	TK	6itt	B	B	n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	Human	Show
	KIT	PDGFR	TK	1t45	A	B	-	Human	Show
	KIT	PDGFR	TK	6mob	A	B	n-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-n'-phenylurea	Human	Show
	KIT	PDGFR	TK	8pqb	A	B	(1~{s})-1-(4-fluorophenyl)-~{n},~{n}-dimethyl-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	8pqe	A	A	~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]prop-2-enamide	Human	Show
	KIT	PDGFR	TK	8pq9	A	A	(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	1pkg	A		adenosine-5'-diphosphate	Human	Show
	KIT	PDGFR	TK	6gqk	B	B	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	7khg	A	B	5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine	Human	Show
	KIT	PDGFR	TK	7khj	A		2-phenyl-5-(1h-pyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine	Human	Show
	KIT	PDGFR	TK	6gqm	A		~{n}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	4hvs	A		5-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-n-[4-(trifluoromethyl)benzyl]pyridin-2-amine	Human	Show
	KIT	PDGFR	TK	6itt	A	B	n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	Human	Show
	KIT	PDGFR	TK	6xv9	B		~{n}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide	Human	Show
	KIT	PDGFR	TK	8pqa	A	A	6-(1-methylpyrazol-4-yl)-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazine	Human	Show
	KIT	PDGFR	TK	8pqc	A	A	(1~{s})-~{n}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	8pqb	A	A	(1~{s})-1-(4-fluorophenyl)-~{n},~{n}-dimethyl-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	7zw8	A	B	~{n}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine	Human	Show
	KIT	PDGFR	TK	8pqc	A	B	(1~{s})-~{n}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	8dfp	A		-	Human	Show
	KIT	PDGFR	TK	8dfm	A		-	Human	Show
	KIT	PDGFR	TK	8pqg	A	B	(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	6gqj	A	B	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	4u0i	A	A	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	KIT	PDGFR	TK	7khg	A	A	5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine	Human	Show
	KIT	PDGFR	TK	3g0e	A	A	n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	KIT	PDGFR	TK	8pqd	A	A	~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]ethanamide	Human	Show
	KIT	PDGFR	TK	6itv	A	A	n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	Human	Show
	KIT	PDGFR	TK	8pqg	A	A	(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	6gqj	A	A	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	6xvb	A		~{n}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide	Human	Show
	KIT	PDGFR	TK	1pkg	B		adenosine-5'-diphosphate	Human	Show
	KIT	PDGFR	TK	8pqa	A	B	6-(1-methylpyrazol-4-yl)-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazine	Human	Show
	KIT	PDGFR	TK	6hh1	A	B	~{n}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{h}-1,2,4-triazol-3-amine	Human	Show
	KIT	PDGFR	TK	8pqf	A	A	methyl ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]carbamate	Human	Show
	KIT	PDGFR	TK	7zy6	A		5-imidazo[1,2-a]pyridin-3-yl-~{n}-[(1~{r})-1-(6-pyrrolidin-1-ylpyridin-3-yl)ethyl]pyridin-3-amine	Human	Show
	KIT	PDGFR	TK	6xvb	B		~{n}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide	Human	Show
	KIT	PDGFR	TK	6gql	B		~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	6itt	B	A	n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	Human	Show
	KIT	PDGFR	TK	1t46	A	A	4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	Human	Show
	KIT	PDGFR	TK	8pqf	A	B	methyl ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]carbamate	Human	Show
	KIT	PDGFR	TK	8pqd	A	B	~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]ethanamide	Human	Show
	KIT	PDGFR	TK	8pq9	A	B	(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine	Human	Show
	KIT	PDGFR	TK	8dfq	A		-	Human	Show
	KIT	PDGFR	TK	6itv	A	B	n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	Human	Show
	KIT	PDGFR	TK	3g0f	B		n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	KIT	PDGFR	TK	6itt	A	A	n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea	Human	Show
	KIT	PDGFR	TK	6kla	A	A	n-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine	Human	Show
	KIT	PDGFR	TK	6xva	A		~{n}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide	Human	Show
	KIT	PDGFR	TK	4u0i	A	B	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	KIT	PDGFR	TK	6gqj	B	A	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	3g0f	A		n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	KIT	PDGFR	TK	6gqk	B	A	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	Show
	KIT	PDGFR	TK	7zw8	A	A	~{n}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam