Mitogen-activated protein kinase 8
Kinase structure
Kinase:MAPK8 (JNK1)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1496
PDB:1UKH
sc-PDB:
KIDFamMap:Search
Release date:2004-08-30
PubMed: 15141161
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):60.7° (17.8Å)
G-rich loop rotation:50.7°
Quality Score:7.6
Resolution:2.35 Å
Missing Residues:1
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I8
I10
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:KPIGSGAQGIVCAVAIKKLRAYRELVLMKCVNKNIIGLLNVYIVMELMD-ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGLA
Sequence structure:KPIGSGAQGIVCAVAIKKLRAYRELVLMKCVNKNIIGLLNVYIVMELMD_ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGL_