Mitogen-activated protein kinase 8
Kinase structure
Kinase:MAPK8 (JNK1)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1496
PDB:3VUD
sc-PDB:
KIDFamMap:Search
Release date:2013-02-13
PubMed: 23020677
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):51.7° (14.7Å)
G-rich loop rotation:79.1°
Quality Score:8
Resolution:3.5 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KPIGSGAQGIVCAVAIKKLRAYRELVLMKCVNKNIIGLLNVYIVMELMD-ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGLA
Sequence structure:KPIGSGAQGIVCAVAIKKLRAYRELVLMKCVNKNIIGLLNVYIVMELMD_ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGLA