Mitogen-activated protein kinase 14
Kinase structure
Kinase:MAPK14 (p38a)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1499
PDB:4E6C
sc-PDB:
KIDFamMap:Search
Release date:2012-10-31
PubMed: 23079240
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):67.3° (20.2Å)
G-rich loop rotation:46.9°
Quality Score:6
Resolution:2.39 Å
Missing Residues:5
Missing Atoms:0

Allosteric Ligand
Allosteric ligand:0O8
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:SPVGSGAYGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG-ADLNNIVKCYIHSADIIHRDLKPSNLAVILDFGLA
Sequence structure:SPVGSG_YGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG_ADLNNIVK_YIHSADIIHRDLKPSNLAVILDF___