Version: 3.2
Updated: 01-Nov-2025
Mitogen-activated protein kinase 14
Kinase structure
Kinase:MAPK14 (p38a)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1499
PDB:3HP5
sc-PDB:
KIDFamMap:Search
Release date:2009-09-29
PubMed: 19751974
Chain:A
Orthosteric ligand:52P
2D structure of the orthosteric ligand
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):-
G-rich loop rotation:-
Quality Score:7.4
Resolution:2.3 Å
Missing Residues:6
Missing Atoms:2
Ligand binding mode
PocketsSubpocketsWaters
front
gate
back
BP-I-A
BP-I-B
Cluster
I4
Ligand
No
Protein
Yes

Allosteric Ligand
Allosteric ligand:I46
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:SPVGSGAYGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG-ADLNNIVKCYIHSADIIHRDLKPSNLAVILDFGLA
Sequence structure:SPVGS_____VCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG_ADLNNIVKCYIHSADIIHRDLKPSNLAVILDFGV_

Ligand affinity
ChEMBL ID:CHEMBL119385
Bioaffinities: 73 records for 26 kinases
Species Kinase (ChEMBL naming) Median Min Max Type Records
Homo sapiensEphrin type-A receptor 15.35.35.3pKd1
Homo sapiensEphrin type-A receptor 25.75.75.7pKd1
Homo sapiensEphrin type-A receptor 4555pKd1
Homo sapiensEphrin type-A receptor 55.75.75.7pKd1
Homo sapiensEphrin type-A receptor 85.55.55.5pKd1
Homo sapiensEphrin type-B receptor 15.25.25.8pKd2
Homo sapiensEphrin type-B receptor 4666pKd1
Homo sapiensEpithelial discoidin domain-containing receptor 1666pKd2
Homo sapiensMacrophage colony stimulating factor receptor5.65.65.6pKd2
Homo sapiensMAP kinase p38 alpha7.24.68.1pIC5012
Homo sapiensMAP kinase p38 alpha8.68.58.6pKd4
Homo sapiensMAP kinase p38 alpha8.38.38.3pKi1
Mus musculusMAP kinase p38 alpha7.77.77.7pIC501
Homo sapiensMAP kinase p38 beta7.16.87.1pKd3
Homo sapiensMAP kinase p38 beta6.76.76.7pKi1
Homo sapiensPlatelet-derived growth factor receptor alpha5.15.15.1pKd1
Homo sapiensPlatelet-derived growth factor receptor beta5.15.16.1pKd3
Homo sapiensProto-oncogene tyrosine-protein kinase ROS6.46.46.4pKi1
Homo sapiensTyrosine-protein kinase ABL5.85.16.2pKd11
Homo sapiensTyrosine-protein kinase ABL25.75.76.7pKd3
Homo sapiensTyrosine-protein kinase BLK5.55.55.5pKd2
Homo sapiensTyrosine-protein kinase FGR5.95.95.9pKd3
Homo sapiensTyrosine-protein kinase FRK5.55.55.5pKd1
Homo sapiensTyrosine-protein kinase FYN5.75.75.7pKd2
Homo sapiensTyrosine-protein kinase HCK555pKd1
Homo sapiensTyrosine-protein kinase LCK5.35.35.8pKd3
Homo sapiensTyrosine-protein kinase Lyn5.85.85.8pKd2
Homo sapiensTyrosine-protein kinase SRC5.35.36pKd3
Homo sapiensTyrosine-protein kinase YES5.85.65.8pKd3


Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
I g.l II III αC
1 S
28		2 P
29		3 V
30		4 G
36		5 S
37		6 _
_		7 _
_		8 _
_		9 _
_		10 _
_		11 V
38		12 C
39		13 A
40		14 V
50		15 A
51		16 V
52		17 K
53		18 K
54		19 L
55		20 R
67
•••••
αC b.l IV
21 T
68		22 Y
69		23 R
70		24 E
71		25 L
72		26 R
73		27 L
74		28 L
75		29 K
76		30 H
77		31 M
78		32 K
79		33 E
81		34 N
82		35 V
83		36 I
84		37 G
85		38 L
86		39 L
87		40 D
88
•••
IV V GK hinge linker αD αE
41 V
89		42 Y
103		43 L
104		44 V
105		45 T
106		46 H
107		47 L
108		48 M
109		49 G
110		50 _
_		51 A
111		52 D
112		53 L
113		54 N
114		55 N
115		56 I
116		57 V
117		58 K
118		59 C
119		60 Y
140
••••••••••
αE VI c.l VII VIII x
61 I
141		62 H
142		63 S
143		64 A
144		65 D
145		66 I
146		67 I
147		68 H
148		69 R
149		70 D
150		71 L
151		72 K
152		73 P
153		74 S
154		75 N
155		76 L
156		77 A
157		78 V
158		79 I
166		80 L
167
••
DFG a.l
81 D
168		82 F
169		83 G
170		84 V
183		85 _
_

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