Mitogen-activated protein kinase 14
Kinase structure
Kinase:MAPK14 (p38a)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1499
PDB:4E5A
sc-PDB:
KIDFamMap:Search
Release date:2012-10-31
PubMed: 23079240
Chain:X
(Alternate) Model:B
Click to open a 3D viewer
The orthosteric binding pocket


More entries for 4E5A
4E5AAlternative model: AChain: X


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):67.9° (20.1Å)
G-rich loop rotation:42.3°
Quality Score:6.4
Resolution:1.87 Å
Missing Residues:4
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I1
I3
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:SPVGSGAYGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG-ADLNNIVKCYIHSADIIHRDLKPSNLAVILDFGLA
Sequence structure:SPVGSGAYGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG_ADLNNIVT_YIHSADIIHRDLKPSNLAVILDF___