Version: 3.2
Updated: 24-Dec-2025
Protein kinase cAMP-activated catalytic subunit alpha
Kinase structure
Kinase:PRKACA (PKACa)
Family:PKA
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1476
PDB:4AE6
sc-PDB:
KIDFamMap:Search
Release date:2012-04-18
PubMed: 22504716
Chain:A
(Alternate) Model:A
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The orthosteric binding pocket


More entries for 4AE6
4AE6Alternative model: AChain: B
4AE6Alternative model: BChain: A
4AE6Alternative model: BChain: B


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):69.7° (20.5Å)
G-rich loop rotation:79.7°
Quality Score:8
Resolution:2.1 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Sequence structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA