Version: 3.2
Updated: 29-Oct-2025
Protein kinase cAMP-activated catalytic subunit alpha
Kinase structure
Kinase:PRKACA (PKACa)
Family:PKA
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1476
PDB:3AGM
sc-PDB:
KIDFamMap:Search
Release date:2010-09-01
PubMed: 20732331
Chain:A
Click to open a 3D viewer
The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):57.9° (17.9Å)
G-rich loop rotation:49.7°
Quality Score:8
Resolution:2 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
I10
I11
Ligand
No
No
No
Protein
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Sequence structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA