Version: 3.2
Updated: 29-Oct-2025
Protein kinase cAMP-activated catalytic subunit alpha
Kinase structure
Kinase:PRKACA (PKACa)
Family:PKA
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1476
PDB:3MVJ
sc-PDB:
KIDFamMap:Search
Release date:2010-06-02
PubMed: 20481595
Chain:B
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The orthosteric binding pocket


More entries for 3MVJ
3MVJChain: A
3MVJChain: E


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):64.2° (20.3Å)
G-rich loop rotation:69.8°
Quality Score:8
Resolution:2.49 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I3
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Sequence structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA