Version: 3.2
Updated: 29-Oct-2025
Protein kinase cAMP-activated catalytic subunit alpha
Kinase structure
Kinase:PRKACA (PKACa)
Family:PKA
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1476
PDB:3NX8
sc-PDB:
KIDFamMap:Search
Release date:2011-07-13
PubMed: 22213702
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 3NX8
3NX8Alternative model: AChain: A


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):47.5° (14.3Å)
G-rich loop rotation:77.9°
Quality Score:9.2
Resolution:2 Å
Missing Residues:0
Missing Atoms:8
Ligand binding mode
Waters
Cluster
I1
I5
I10
I11
Ligand
No
No
No
No
Protein
Yes
Yes
Yes
Yes

Pocket alignment
Uniprot sequence:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Sequence structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA