Insulin receptor
Kinase structure
Kinase:INSR
Family:InsR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1800
PDB:1GAG
sc-PDB:
KIDFamMap:Search
Release date:2001-01-17
PubMed: 11135668
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58.2° (17.2Å)
G-rich loop rotation:66.7°
Quality Score:8
Resolution:2.7 Å
Missing Residues:0
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT-HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT
Sequence structure:RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT_HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT