Insulin receptor
Kinase structure
Kinase:INSR
Family:InsR
Group:TK
Species:HUMAN
IUPHAR/BPS ID:1800
PDB:1P14
sc-PDB:
KIDFamMap:Search
Release date:2003-07-22
PubMed: 12707268
Chain:A
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The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58.9° (17.3Å)
G-rich loop rotation:77.5°
Quality Score:7.2
Resolution:1.9 Å
Missing Residues:2
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I5
I6
I10
I11
Ligand
No
No
No
No
Protein
Yes
No
Yes
Yes

Pocket alignment
Uniprot sequence:RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT-HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT
Sequence structure:RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT_HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRNLAARNCMVIGDFG__