Mitogen-activated protein kinase 8
Kinase structure
Kinase:MAPK8 (JNK1)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1496
PDB:4YR8
sc-PDB:
KIDFamMap:Search
Release date:2016-03-16
PubMed: 26988444
Chain:A
(Alternate) Model:B
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The orthosteric binding pocket


More entries for 4YR8
4YR8Alternative model: AChain: A
4YR8Alternative model: AChain: C
4YR8Alternative model: AChain: E
4YR8Alternative model: AChain: F
4YR8Alternative model: BChain: C
4YR8Alternative model: BChain: E
4YR8Alternative model: BChain: F


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):-
G-rich loop rotation:-
Quality Score:8.2
Resolution:2.4 Å
Missing Residues:4
Missing Atoms:2
Ligand binding mode
Waters
Cluster
I8
Ligand
No
Protein
Yes

Pocket alignment
Uniprot sequence:KPIGSGAQGIVCAVAIKKLRAYRELVLMKCVNKNIIGLLNVYIVMELMD-ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGLA
Sequence structure:KPIG____GIVCAVAIKKLRAYRELVLMKCVNKNIIGLLNVYIVMELMD_ANLCQVIQMHLHSAGIIHRDLKPSNIVVILDFGLA