Transforming growth factor beta receptor I
Kinase structure
Kinase:TGFBR1 (TGFbR1)
Family:STKR
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:1788
PDB:5E8U
sc-PDB:
KIDFamMap:Search
Release date:2016-05-11
PubMed: 27139629
Chain:A
Click to open a 3D viewer
The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):49.6° (14.7Å)
G-rich loop rotation:68.9°
Quality Score:9.6
Resolution:2.03 Å
Missing Residues:0
Missing Atoms:4
Ligand binding mode
Waters
Cluster
I5
I8
Ligand
No
No
Protein
Yes
Yes

Pocket alignment
Uniprot sequence:ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA
Sequence structure:ESVGKGRFGEVWRVAVKIFSWFREAEIFQTVMENILGFIAAWLVTDFHEHGNLFDYLNRTQGKPAIAHRDLKSKNILVICDFGLA