B-Raf proto-oncogene, serine/threonine kinase
Kinase structure
Kinase:BRAF
Family:RAF
Group:TKL
Species:HUMAN
IUPHAR/BPS ID:1943
PDB:5JT2
sc-PDB:
KIDFamMap:Search
Release date:2016-09-14
PubMed: 27571413
Chain:B
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The orthosteric binding pocket


More entries for 5JT2
5JT2Chain: A
5JT2Chain: C
5JT2Chain: D


Structural information
DFG conformation:in
αC-helix conformation:out
G-rich loop angle (distance):45.9° (13.5Å)
G-rich loop rotation:67.6°
Quality Score:8.4
Resolution:2.7 Å
Missing Residues:0
Missing Atoms:16
Ligand binding mode
Waters
Cluster
I2
Ligand
No
Protein
No

Allosteric Ligand
Allosteric ligand:BEN
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQWCEGSSLYHHLHIYLHAKSIIHRDLKSNNIFLIGDFGLA
Sequence structure:QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQWCEGSSLYHHLHAYLHAKSIIHRDLKSNNIFLIGDFGLA