Search results (234 entries covering 102 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	BRAF	RAF	TKL	9bfb	A	B	n-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	9bfb	A	A	n-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	7shv	A	B	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	7shv	A	A	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	5vam	B	A	n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	6pp9	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	3psd	A		6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl]indeno[1,2-c]pyrazole	Human	Show
	BRAF	RAF	TKL	5jt2	D		-	Human	Show
	BRAF	RAF	TKL	6v2w	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	7m0t	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	5csw	A		dabrafenib	Human	Show
	BRAF	RAF	TKL	5fd2	B		6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{h}-purine	Human	Show
	BRAF	RAF	TKL	4mne	G	A	-	Human	Show
	BRAF	RAF	TKL	6b8u	A		~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	6p3d	A		3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	5jsm	A	B	-	Human	Show
	BRAF	RAF	TKL	6uan	B		-	Human	Show
	BRAF	RAF	TKL	4mnf	A	B	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	8c7y	A	A	~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide	Human	Show
	BRAF	RAF	TKL	8c7y	A	B	~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide	Human	Show
	BRAF	RAF	TKL	8f7p	A	B	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	8f7o	A	B	6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	8f7p	A	A	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	8c7x	A	B	~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide	Human	Show
	BRAF	RAF	TKL	8c7x	A	A	~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide	Human	Show
	BRAF	RAF	TKL	8f7o	A	A	6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	4mne	F	A	-	Human	Show
	BRAF	RAF	TKL	4xv1	B		-	Human	Show
	BRAF	RAF	TKL	4pp7	B		n-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	3skc	A		2,6-difluoro-n-[(5s)-3-methoxy-5h-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	5jsm	C	B	n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)	Human	Show
	BRAF	RAF	TKL	6cad	B		1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	Show
	BRAF	RAF	TKL	4g9c	A		3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)benzamide	Human	Show
	BRAF	RAF	TKL	6u2h	D	A	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	3tv4	A		n-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	5jsm	D	B	-	Human	Show
	BRAF	RAF	TKL	7m0y	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6nsq	B		5-[(4-amino-1-ethyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-n-(4-chlorophenyl)-6-methylisoquinolin-1-amine	Human	Show
	BRAF	RAF	TKL	4fk3	A		n-{2,4-difluoro-3-[(5-pyridin-3-yl-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide	Human	Show
	BRAF	RAF	TKL	5csx	A		n-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	5c9c	B	B	1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea	Human	Show
	BRAF	RAF	TKL	6p7g	C		3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide	Human	Show
	BRAF	RAF	TKL	8dgt	A	B	phosphothiophosphoric acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6p7g	B		3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide	Human	Show
	BRAF	RAF	TKL	4rzv	A		n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	4mnf	B	A	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	5c9c	B	A	1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea	Human	Show
	BRAF	RAF	TKL	4mne	G	B	-	Human	Show
	BRAF	RAF	TKL	4xv2	A		dabrafenib	Human	Show
	BRAF	RAF	TKL	6q0j	B	B	-	Human	Show
	BRAF	RAF	TKL	5jsm	D	A	-	Human	Show
	BRAF	RAF	TKL	4rzw	B		3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	4wo5	B		n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	5vam	B	B	n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	3prf	B		2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol	Human	Show
	BRAF	RAF	TKL	7p3v	A		~{n}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{s})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide	Human	Show
	BRAF	RAF	TKL	6q0j	B	A	-	Human	Show
	BRAF	RAF	TKL	3tv6	A		2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	5jsm	A	A	-	Human	Show
	BRAF	RAF	TKL	7m0z	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	5jsm	C	A	n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)	Human	Show
	BRAF	RAF	TKL	4xv1	A		n'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-n-ethyl-n-methylsulfuric diamide	Human	Show
	BRAF	RAF	TKL	6uuo	B		1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-5-yl](methyl)amino}pyridin-1(4h)-yl]ethan-1-one	Human	Show
	BRAF	RAF	TKL	5ct7	B		1-methyl-5-({2-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-4-yl}oxy)-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine	Human	Show
	BRAF	RAF	TKL	5hie	D	A	dabrafenib	Human	Show
	BRAF	RAF	TKL	6u2h	C	A	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	6q0j	A	A	-	Human	Show
	BRAF	RAF	TKL	3ii5	A		n-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	5hid	B	B	3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	3psb	B		ethyl 3-{[1-(hydroxyamino)-2h-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate	Human	Show
	BRAF	RAF	TKL	4r5y	B		5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one	Human	Show
	BRAF	RAF	TKL	6n0q	B	A	n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	6q0t	B	B	-	Human	Show
	BRAF	RAF	TKL	4pp7	A		n-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	5jt2	B		-	Human	Show
	BRAF	RAF	TKL	4fc0	B		2-chloro-3-[(2-cyanopropan-2-yl)oxy]-n-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide	Human	Show
	BRAF	RAF	TKL	5hie	A	A	dabrafenib	Human	Show
	BRAF	RAF	TKL	4mne	B	A	-	Human	Show
	BRAF	RAF	TKL	2fb8	A		(1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oxime	Human	Show
	BRAF	RAF	TKL	5jrq	B		(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]methanone	Human	Show
	BRAF	RAF	TKL	3tv4	B		n-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	1uwj	B		4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	4xv3	A		n'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-n-ethyl-n-methylsulfuric diamide	Human	Show
	BRAF	RAF	TKL	5hid	A	A	3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	3ii5	B		n-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	5hie	C	B	dabrafenib	Human	Show
	BRAF	RAF	TKL	4xv3	B		-	Human	Show
	BRAF	RAF	TKL	5fd2	A		6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{h}-purine	Human	Show
	BRAF	RAF	TKL	4rzw	A		3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	2fb8	B		(1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oxime	Human	Show
	BRAF	RAF	TKL	5hie	B	B	dabrafenib	Human	Show
	BRAF	RAF	TKL	4ksq	B		n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide	Human	Show
	BRAF	RAF	TKL	6u2g	B		phosphomethylphosphonic acid adenylate ester	Human	Show
	BRAF	RAF	TKL	3ppj	B		methyl 3-{[(5s)-1-(hydroxyamino)-5h-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate	Human	Show
	BRAF	RAF	TKL	4dbn	A		2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide	Human	Show
	BRAF	RAF	TKL	4cqe	B		n-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide	Human	Show
	BRAF	RAF	TKL	5csw	B		dabrafenib	Human	Show
	BRAF	RAF	TKL	6v2w	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6n0p	A	A	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	3q96	A		(2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide	Human	Show
	BRAF	RAF	TKL	3og7	B		-	Human	Show
	BRAF	RAF	TKL	4e4x	B		n-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	6v34	A		6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	6cad	A		1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	Show
	BRAF	RAF	TKL	3idp	A		n~1~-(4-chlorophenyl)-6-methyl-n~5~-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine	Human	Show
	BRAF	RAF	TKL	4rzv	B		n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	4jvg	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	Show
	BRAF	RAF	TKL	4jvg	B		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	Show
	BRAF	RAF	TKL	4h58	A	B	n-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine	Human	Show
	BRAF	RAF	TKL	5hie	C	A	dabrafenib	Human	Show
	BRAF	RAF	TKL	3idp	B		n~1~-(4-chlorophenyl)-6-methyl-n~5~-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine	Human	Show
	BRAF	RAF	TKL	1uwh	A		4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	4xv9	A	A	n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide	Human	Show
	BRAF	RAF	TKL	4r5y	A		5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one	Human	Show
	BRAF	RAF	TKL	6p7g	A		3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide	Human	Show
	BRAF	RAF	TKL	3d4q	A		(1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oxime	Human	Show
	BRAF	RAF	TKL	6n0p	A	B	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	5hid	A	B	3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	4xv9	A	B	n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide	Human	Show
	BRAF	RAF	TKL	6xag	C	A	-	Human	Show
	BRAF	RAF	TKL	4e4x	A		n-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	3skc	B		2,6-difluoro-n-[(5s)-3-methoxy-5h-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	6q0t	A	B	-	Human	Show
	BRAF	RAF	TKL	4mne	C	A	-	Human	Show
	BRAF	RAF	TKL	6q0t	A	A	-	Human	Show
	BRAF	RAF	TKL	3q4c	B		-	Human	Show
	BRAF	RAF	TKL	3psb	A		ethyl 3-{[1-(hydroxyamino)-2h-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate	Human	Show
	BRAF	RAF	TKL	6nyb	A		phosphothiophosphoric acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6n0q	A	B	n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	4ksp	A		n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide	Human	Show
	BRAF	RAF	TKL	4h58	C	A	-	Human	Show
	BRAF	RAF	TKL	4mnf	B	B	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	4h58	B	A	-	Human	Show
	BRAF	RAF	TKL	4ehg	A		n-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	5jsm	B	B	n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)	Human	Show
	BRAF	RAF	TKL	5hie	D	B	dabrafenib	Human	Show
	BRAF	RAF	TKL	4h58	B	B	-	Human	Show
	BRAF	RAF	TKL	6pp9	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6xfp	A	A	4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide	Human	Show
	BRAF	RAF	TKL	7k0v	A	A	n-(3,3-dimethylbutyl)-n'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea	Human	Show
	BRAF	RAF	TKL	6nsq	A		5-[(4-amino-1-ethyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-n-(4-chlorophenyl)-6-methylisoquinolin-1-amine	Human	Show
	BRAF	RAF	TKL	6v2u	B		dabrafenib	Human	Show
	BRAF	RAF	TKL	5vam	A	B	n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	3d4q	B		(1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oxime	Human	Show
	BRAF	RAF	TKL	4jvg	D		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	Show
	BRAF	RAF	TKL	4fc0	A		2-chloro-3-[(2-cyanopropan-2-yl)oxy]-n-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide	Human	Show
	BRAF	RAF	TKL	5hie	B	A	dabrafenib	Human	Show
	BRAF	RAF	TKL	7m0v	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6n0q	A	A	n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	3tv6	B		2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	6v2u	A		dabrafenib	Human	Show
	BRAF	RAF	TKL	4yht	B		3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide	Human	Show
	BRAF	RAF	TKL	6n0p	B	B	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	5jt2	A		2,2'-oxybis[n-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide]	Human	Show
	BRAF	RAF	TKL	3og7	A		n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	7m0w	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	4yht	A		3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide	Human	Show
	BRAF	RAF	TKL	8dgs	A	B	phosphothiophosphoric acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	8dgt	A	A	phosphothiophosphoric acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	8dgs	A	A	phosphothiophosphoric acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6p7g	D		3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide	Human	Show
	BRAF	RAF	TKL	6n0q	B	B	n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	7k0v	A	B	n-(3,3-dimethylbutyl)-n'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea	Human	Show
	BRAF	RAF	TKL	5c9c	A	A	1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea	Human	Show
	BRAF	RAF	TKL	8qqg	A	B	(3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide	Human	Show
	BRAF	RAF	TKL	8qqg	A	A	(3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide	Human	Show
	BRAF	RAF	TKL	5ita	B		n-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	5ita	A		n-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	4mne	C	B	-	Human	Show
	BRAF	RAF	TKL	4h58	A	A	n-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine	Human	Show
	BRAF	RAF	TKL	4mne	B	B	-	Human	Show
	BRAF	RAF	TKL	6q0k	B		-	Human	Show
	BRAF	RAF	TKL	4jvg	C		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	Show
	BRAF	RAF	TKL	3pri	A		3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1h-indazol-3-yl)propan-1-ol	Human	Show
	BRAF	RAF	TKL	3ppk	A		3-[(5-hydroxynaphthalen-2-yl)amino]-n-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	7mfd	A		-	Human	Show
	BRAF	RAF	TKL	6q0t	B	A	-	Human	Show
	BRAF	RAF	TKL	5ct7	A		1-methyl-5-({2-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-4-yl}oxy)-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine	Human	Show
	BRAF	RAF	TKL	4fk3	B		-	Human	Show
	BRAF	RAF	TKL	4h58	C	B	-	Human	Show
	BRAF	RAF	TKL	5jsm	B	A	n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide)	Human	Show
	BRAF	RAF	TKL	6uan	C		-	Human	Show
	BRAF	RAF	TKL	7mfe	A		-	Human	Show
	BRAF	RAF	TKL	4wo5	A		n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	6v34	B		6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	6xlo	A		3-(2-cyanopropan-2-yl)-n-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide	Human	Show
	BRAF	RAF	TKL	4g9c	B		3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)benzamide	Human	Show
	BRAF	RAF	TKL	3psd	B		6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl]indeno[1,2-c]pyrazole	Human	Show
	BRAF	RAF	TKL	3q4c	A		[(1,2,3,4,5,6-eta)-(1s,2r,3r,4r,5s,6s)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5h-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~n~1~,n~12~)ruthenium(1+)	Human	Show
	BRAF	RAF	TKL	6xfp	A	B	4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide	Human	Show
	BRAF	RAF	TKL	5val	B		n-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide	Human	Show
	BRAF	RAF	TKL	5jrq	A		(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]methanone	Human	Show
	BRAF	RAF	TKL	7m0v	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	3c4c	A		n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	4e26	B		5-chloro-7-[(r)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol	Human	Show
	BRAF	RAF	TKL	5vam	A	A	n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	4ksq	A		n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide	Human	Show
	BRAF	RAF	TKL	1uwh	B		4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	3pri	B		3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1h-indazol-3-yl)propan-1-ol	Human	Show
	BRAF	RAF	TKL	4g9r	A		3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	7m0x	A	B	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	4dbn	B		2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide	Human	Show
	BRAF	RAF	TKL	4cqe	A		n-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide	Human	Show
	BRAF	RAF	TKL	6xag	D	A	-	Human	Show
	BRAF	RAF	TKL	5val	A		n-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide	Human	Show
	BRAF	RAF	TKL	7m0x	A	A	phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	6n0p	B	A	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	Show
	BRAF	RAF	TKL	4e26	A		5-chloro-7-[(r)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol	Human	Show
	BRAF	RAF	TKL	6uuo	A		1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-5-yl](methyl)amino}pyridin-1(4h)-yl]ethan-1-one	Human	Show
	BRAF	RAF	TKL	4xv2	B		dabrafenib	Human	Show
	BRAF	RAF	TKL	1uwj	A		4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	5hid	B	A	3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	4mne	F	B	-	Human	Show
	BRAF	RAF	TKL	6q0j	A	B	-	Human	Show
	BRAF	RAF	TKL	4ehe	A		4-amino-n-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide	Human	Show
	BRAF	RAF	TKL	6b8u	B		~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide	Human	Show
	BRAF	RAF	TKL	3prf	A		2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol	Human	Show
	BRAF	RAF	TKL	3ppj	A		methyl 3-{[(5s)-1-(hydroxyamino)-5h-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate	Human	Show
	BRAF	RAF	TKL	5hie	A	B	dabrafenib	Human	Show
	BRAF	RAF	TKL	3q96	B		(2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide	Human	Show
	BRAF	RAF	TKL	7m0u	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	BRAF	RAF	TKL	5jt2	C		2,2'-oxybis[n-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide]	Human	Show
	BRAF	RAF	TKL	5c9c	A	B	1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea	Human	Show
	BRAF	RAF	TKL	4mbj	B		2,6-difluoro-n-(1h-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	3c4c	B		n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	5hi2	A		4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	4ehe	B		4-amino-n-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide	Human	Show
	BRAF	RAF	TKL	6q0k	A		-	Human	Show
	BRAF	RAF	TKL	3ppk	B		3-[(5-hydroxynaphthalen-2-yl)amino]-n-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide	Human	Show
	BRAF	RAF	TKL	4g9r	B		3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	Human	Show
	BRAF	RAF	TKL	4ehg	B		n-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide	Human	Show
	BRAF	RAF	TKL	4mbj	A		2,6-difluoro-n-(1h-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide	Human	Show
	BRAF	RAF	TKL	4mnf	A	A	2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol	Human	Show
	BRAF	RAF	TKL	4ksp	B		n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam