Version: 3.2
Updated: 01-Nov-2025
Rho associated coiled-coil containing protein kinase 2
Kinase structure
Kinase:ROCK2
Family:DMPK
Group:AGC
Species:HUMAN
IUPHAR/BPS ID:1504
PDB:5U7Q
sc-PDB:
KIDFamMap:Search
Release date:2017-03-29
PubMed: 28284870
Chain:A
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The orthosteric binding pocket


More entries for 5U7Q
5U7QChain: B
5U7QChain: C
5U7QChain: D


Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):58.4° (17.9Å)
G-rich loop rotation:77.6°
Quality Score:8
Resolution:3.15 Å
Missing Residues:0
Missing Atoms:0

Pocket alignment
Uniprot sequence:KVIGRGAFGEVQLYAMKLLFFWEERDIMAFANPWVVQLFYAYMVMEYMPGGDLVNLMSNAIHSMGLIHRDVKPDNMLLLADFGTC
Sequence structure:KVIGRGAFGEVQLYAMKLLFFWEERDIMAFANPWVVQLFYAYMVMEYMPGGDLVNLMSNAIHSMGLIHRDVKPDNMLLLADFGTC