KLIFS - the kinase structures database

Version: 3.2
Updated: 01-Nov-2025

Search results (54 entries covering 11 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details
ROCK2	DMPK	AGC	6p5m	A	B	6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	7jov	F		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	4wot	D		methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate	Human	Show
ROCK2	DMPK	AGC	4l6q	A		6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3h)-ol	Human	Show
ROCK2	DMPK	AGC	6p5m	D	A	-	Human	Show
ROCK2	DMPK	AGC	7jov	B		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	6p5p	C		2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	7jnt	B	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	A	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	5u7q	B		-	Human	Show
ROCK2	DMPK	AGC	6p5p	A		2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	7p6n	A		~{n}-[(1~{r})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide	Human	Show
ROCK2	DMPK	AGC	8gds	A		4-{4-[2-(2,3-dihydro-1h-indol-1-yl)-2-oxoethyl]phenyl}phthalazin-1(2h)-one	Human	Show
ROCK2	DMPK	AGC	7jnt	G	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jov	C		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	6p5m	B	A	6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	6p5p	B		2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	7jnt	D	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	6p5m	B	B	6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	6ed6	B		n-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	4wot	C		methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate	Human	Show
ROCK2	DMPK	AGC	7jnt	B	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	A	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	C	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	E	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	F	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	D	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	5u7r	C		(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-one	Human	Show
ROCK2	DMPK	AGC	7jov	H		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	6ed6	A		n-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	6p5m	A	A	6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	7jnt	C	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jnt	H	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	7jov	A		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	5u7q	A		-	Human	Show
ROCK2	DMPK	AGC	4wot	A		methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate	Human	Show
ROCK2	DMPK	AGC	7jnt	F	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	6p5p	D		2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one	Human	Show
ROCK2	DMPK	AGC	6p5m	C	A	-	Human	Show
ROCK2	DMPK	AGC	7jnt	H	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	4l6q	B		6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3h)-ol	Human	Show
ROCK2	DMPK	AGC	6p5m	D	B	-	Human	Show
ROCK2	DMPK	AGC	7jnt	G	A	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show
ROCK2	DMPK	AGC	5u7r	D		(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-one	Human	Show
ROCK2	DMPK	AGC	6p5m	C	B	-	Human	Show
ROCK2	DMPK	AGC	7jov	E		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	7jov	G		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	5u7q	C		-	Human	Show
ROCK2	DMPK	AGC	5u7q	D		-	Human	Show
ROCK2	DMPK	AGC	7jov	D		n-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamide	Human	Show
ROCK2	DMPK	AGC	4wot	B		methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate	Human	Show
ROCK2	DMPK	AGC	5u7r	B		(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-one	Human	Show
ROCK2	DMPK	AGC	5u7r	A		(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-one	Human	Show
ROCK2	DMPK	AGC	7jnt	E	B	n-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamide	Human	Show