PDB-code
| Kinase structure | |
| Kinase: | JAK2-b |
| Family: | JakB |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2048 |
| PDB: | 5USZ |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2017-06-07 |
| PubMed: | 28626521 |
| Chain: | A |
| (Alternate) Model: | A |
| Orthosteric ligand: | SKE |
 | |
| More entries for 5USZ | |||||
| 5USZ | Alternative model: | B | Chain: | A | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 51.8° (15.2Å) |
| G-rich loop rotation: | 70.4° |
| Quality Score: | 8 |
| Resolution: | 2.1 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 32 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-I | Cluster I1 | Ligand Yes | Protein Yes |
| Pocket alignment | |
| Uniprot sequence: | ESLGQGTFTKIFKVLLKVLESFFEAASMMSKLKHLVLNYGVILVQEFVKFGSLDTYLKKFLEENTLIHGNVCAKNILLTGNPPFI |
| Sequence structure: | ESLGQGTFTKIFKVLLKVLESFFEAASMSKLSKHLVLNYGVILVQEFVKFGSLDTYLKKFLEENTLIHGNVCAKNILLLSDPGIS |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL191003 |
| Bioaffinities: | 243 records for 154 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 5.5 | 5.5 | 5.5 | pKi | 1 |
| Homo sapiens | Activin receptor type-2A | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Activin receptor type-2B | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Casein kinase I epsilon | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase I gamma 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Casein kinase I gamma 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Casein kinase I isoform gamma-3 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Chaperone activity of bc1 complex-like, mitochondrial | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 1 | 8.2 | 8.2 | 8.2 | pIC50 | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 8.7 | 8.7 | 8.7 | pIC50 | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 7.9 | 7.9 | 7.9 | pIC50 | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 9.3 | 9.3 | 9.3 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 9 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 9 | 7.8 | 7.8 | 7.8 | pKi | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.4 | 5.4 | 5.4 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase CLK3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Dual specificity testis-specific protein kinase 1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 7 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 6.2 | 6.2 | 6.3 | pKd | 2 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | G protein-coupled receptor kinase 5 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Interferon-induced, double-stranded RNA-activated protein kinase | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | LIM domain kinase 2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase 15 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 6 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Myotonin-protein kinase | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Protein kinase C delta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase C mu | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Protein kinase C theta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 1 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 5.4 | 5.4 | 5.4 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 6.4 | 6.4 | 6.4 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 6 | 6 | 6 | pKi | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 5.5 | 5.5 | 5.5 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 7.2 | 6.6 | 7.5 | pKd | 6 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 8.4 | 8.4 | 8.4 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase GAK | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MARK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK6 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase receptor R3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 5.8 | 5.6 | 6.2 | pKd | 6 |
| Homo sapiens | Stem cell growth factor receptor | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 5.9 | 5.7 | 7.2 | pKd | 7 |
| Homo sapiens | Tyrosine-protein kinase ABL | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 7.7 | 7.7 | 7.7 | pKd | 6 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 6.7 | 6.1 | 7.5 | pKd | 10 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 7 | 7 | 7 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 6.8 | 6.8 | 6.8 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 6.7 | 6.7 | 6.7 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 5.6 | 5.6 | 5.6 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 6.1 | 5.9 | 6.2 | pKd | 5 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 5.4 | 5.4 | 6 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 7.5 | 7.5 | 7.5 | pKd | 4 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.9 | 6.9 | 6.9 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 6 | 6 | 6 | pKd | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 549 | 2 S 550 | 3 L 551 | 4 G 552 | 5 Q 553 | 6 G 554 | 7 T 555 | 8 F 556 | 9 T 557 | 10 K 558 | 11 I 559 | 12 F 560 | 13 K 561 | 14 V 578 | 15 L 579 | 16 L 580 | 17 K 581 | 18 V 582 | 19 L 583 | 20 E 592 |
| • | • | • | • | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 S 593 | 22 F 594 | 23 F 595 | 24 E 596 | 25 A 597 | 26 A 598 | 27 S 599 | 28 M 601 | 29 S 602 | 30 K 603 | 31 L 604 | 32 S 605 | 33 K 607 | 34 H 608 | 35 L 609 | 36 V 610 | 37 L 611 | 38 N 612 | 39 Y 613 | 40 G 614 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 615 | 42 I 623 | 43 L 624 | 44 V 625 | 45 Q 626 | 46 E 627 | 47 F 628 | 48 V 629 | 49 K 630 | 50 F 631 | 51 G 632 | 52 S 633 | 53 L 634 | 54 D 635 | 55 T 636 | 56 Y 637 | 57 L 638 | 58 K 639 | 59 K 640 | 60 F 663 |
| • | • | •• | ••• | • | • | • | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 664 | 62 E 665 | 63 E 666 | 64 N 667 | 65 T 668 | 66 L 669 | 67 I 670 | 68 H 671 | 69 G 672 | 70 N 673 | 71 V 674 | 72 C 675 | 73 A 676 | 74 K 677 | 75 N 678 | 76 I 679 | 77 L 680 | 78 L 681 | 79 L 697 | 80 S 698 |
| • | • | • | •• | ||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 699 | 82 P 700 | 83 G 701 | 84 I 702 | 85 S 703 | |||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
