Mitogen-activated protein kinase 14
Kinase structure
Kinase:MAPK14 (p38a)
Family:MAPK
Group:CMGC
Species:HUMAN
IUPHAR/BPS ID:1499
PDB:5N68
sc-PDB:
KIDFamMap:Search
Release date:2017-09-20
PubMed: 28892510
Chain:A
Click to open a 3D viewer
The orthosteric binding pocket
Structural information
DFG conformation:in
αC-helix conformation:in
G-rich loop angle (distance):-
G-rich loop rotation:-
Quality Score:5.2
Resolution:1.85 Å
Missing Residues:7
Missing Atoms:0
Ligand binding mode
Waters
Cluster
I4
Ligand
No
Protein
Yes

Allosteric Ligand
Allosteric ligand:8OK
2D structure of the allostericligand
Pocket alignment
Uniprot sequence:SPVGSGAYGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG-ADLNNIVKCYIHSADIIHRDLKPSNLAVILDFGLA
Sequence structure:SPVGS__YGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG_ADLNNI___YIHSADIIHRDLKPSNLAVILDFG__