PDB-code
| Kinase structure | |
| Kinase: | MTOR (FRAP) |
| Family: | PIKK |
| Group: | Atypical |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 2109 |
| PDB: | 4JT5 |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2013-05-08 |
| PubMed: | 23636326 |
| Chain: | A |
| Orthosteric ligand: | P2X |
 | |
| More entries for 4JT5 | |||
| 4JT5 | Chain: | B | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 58.9° (18.2Å) |
| G-rich loop rotation: | 69.3° |
| Quality Score: | 8 |
| Resolution: | 3.45 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | |||
| front gate back | BP-I-B | |||
| Pocket alignment | |
| Uniprot sequence: | LQVITSKQRPRKLFLLKGHDLRQDERVMQLFGLSIQRYAVISGLIGWVPCDTLHALIRDVGYI--LGLGDRHPSNLMLHIDFGDC |
| Sequence structure: | LQVITSKQRPRKLFLLKGHDLRQDERVMQLFGLSIQRYAVISGLIGWVPCDTLHALIRDVGYI__LGLGDRHPSNLMLHIDFGDC |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL1241674 |
| Bioaffinities: | 260 records for 193 kinases |
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | Activin receptor type-1 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Activin receptor type-1B | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Activin receptor type-2A | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Activin receptor type-2B | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-1A | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-1B | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase I alpha | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Casein kinase I delta | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Casein kinase I epsilon | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Casein kinase I gamma 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase I gamma 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Casein kinase I isoform alpha-like | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Casein kinase I isoform gamma-3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Cell division cycle 2-like protein kinase 6 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Cell division protein kinase 8 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | cGMP-dependent protein kinase 2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Chaperone activity of bc1 complex-like, mitochondrial | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 4 | 5.1 | 5.1 | 5.1 | pKd | 2 |
| Homo sapiens | Cyclin-dependent kinase 7 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 1 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | DNA-dependent protein kinase | 6.4 | 6.4 | 6.4 | pIC50 | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Dual specificity testis-specific protein kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 5 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 8 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 5.5 | 5.5 | 5.5 | pIC50 | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 5.4 | 5.4 | 5.4 | pIC50 | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 5.6 | 5.3 | 6.7 | pKd | 12 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 6.1 | 6.1 | 6.2 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Interferon-induced, double-stranded RNA-activated protein kinase | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 5.8 | 5.8 | 6.5 | pKd | 2 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | MAP kinase-interacting serine/threonine-protein kinase MNK1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Mixed lineage kinase 7 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Myosin IIIA | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Myotonin-protein kinase | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Protein kinase C epsilon | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Protein kinase C eta | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Receptor tyrosine-protein kinase erbB-3 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Rhodopsin kinase | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 5.7 | 5.7 | 5.7 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 6.7 | 6.7 | 6.7 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 7.2 | 7.2 | 7.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 5 | 5.8 | 5.8 | 5.8 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 6 | 5.1 | 5.1 | 6.2 | pKd | 4 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17B | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32A | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32B | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase AKT3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase B-raf | 5.8 | 5.8 | 6.1 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase GAK | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase mTOR | 8.1 | 8.1 | 8.1 | pIC50 | 3 |
| Homo sapiens | Serine/threonine-protein kinase mTOR | 8.5 | 8.5 | 8.5 | pKd | 2 |
| Homo sapiens | Serine/threonine protein kinase NLK | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK6 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PIM1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PIM2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PIM3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase receptor R3 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO2 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIPK2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO3 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK2 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 6.4 | 5.5 | 6.6 | pKd | 7 |
| Homo sapiens | TGF-beta receptor type I | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | TGF-beta receptor type II | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 5.4 | 5.4 | 6.4 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase ABL | 6.9 | 5.9 | 7.3 | pKd | 13 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase CSK | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 5.4 | 5.4 | 6.5 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 8 | 8 | 8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 7.1 | 7.1 | 7.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 5.9 | 5 | 6.3 | pKd | 7 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 6.5 | 6.5 | 8.4 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 5.5 | 5.5 | 6.6 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase YES | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Uncharacterized aarF domain-containing protein kinase 4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.8 | 5.8 | 5.8 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 L 2160 | 2 Q 2161 | 3 V 2162 | 4 I 2163 | 5 T 2164 | 6 S 2165 | 7 K 2166 | 8 Q 2167 | 9 R 2168 | 10 P 2169 | 11 R 2170 | 12 K 2171 | 13 L 2172 | 14 F 2184 | 15 L 2185 | 16 L 2186 | 17 K 2187 | 18 G 2188 | 19 H 2189 | 20 D 2191 |
| • | • | ||||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 2192 | 22 R 2193 | 23 Q 2194 | 24 D 2195 | 25 E 2196 | 26 R 2197 | 27 V 2198 | 28 M 2199 | 29 Q 2200 | 30 L 2201 | 31 F 2202 | 32 G 2203 | 33 L 2220 | 34 S 2221 | 35 I 2222 | 36 Q 2223 | 37 R 2224 | 38 Y 2225 | 39 A 2226 | 40 V 2227 |
| • | •• | •• | |||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 2228 | 42 S 2234 | 43 G 2235 | 44 L 2236 | 45 I 2237 | 46 G 2238 | 47 W 2239 | 48 V 2240 | 49 P 2241 | 50 C 2243 | 51 D 2244 | 52 T 2245 | 53 L 2246 | 54 H 2247 | 55 A 2248 | 56 L 2249 | 57 I 2250 | 58 R 2251 | 59 D 2252 | 60 V 2330 |
| • | • | •• | •• | • | |||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 G 2331 | 62 Y 2332 | 63 I 2333 | 64 _ _ | 65 _ _ | 66 L 2334 | 67 G 2335 | 68 L 2336 | 69 G 2337 | 70 D 2338 | 71 R 2339 | 72 H 2340 | 73 P 2341 | 74 S 2342 | 75 N 2343 | 76 L 2344 | 77 M 2345 | 78 L 2346 | 79 H 2355 | 80 I 2356 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 2357 | 82 F 2358 | 83 G 2359 | 84 D 2360 | 85 C 2361 | |||||||||||||||
| • | • | ||||||||||||||||||
Interaction pattern search
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